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Production process of enteric hollow capsule

A technology of hollow capsules and production process, which is applied in the direction of capsule transportation, medical preparations of non-active ingredients, inorganic non-active ingredients, etc. It can solve the problems of low product qualification rate, large difference in capsule weight, slow drying and forming, etc., and achieve High surface finish, small weight difference, fast drying and forming effect

Inactive Publication Date: 2010-06-16
ANHUI HUANGSHAN CAPSULE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The enteric-coated empty capsules produced in the past are made by first dipping the gelatin solution on the mold to form a skeleton layer, and then dipping the enteric-coating solution once to form a coating layer. Since the thickness of the coating layer should reach 2~ 3 microns, so the drying is slow and there are wrinkles, and the surface of the capsule is prone to air bubbles
And because the thickness of the coating layer is dipped in the coating solution once, the thickness of the hollow capsules is uneven, not only the weight of the capsules varies greatly, but also the unqualified products that are prone to disintegrate in the gastric juice, and because the surface finish of the capsules is poor, the The qualified rate of the product is low when filling the powder on the filling machine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Alcohol and acetone are mixed into a mixed solution for subsequent use, and its alcohol weight percentage is 10%, and acetone is 90% by weight; 1kg hydroxypropyl methylcellulose phthalate is dissolved in the above-mentioned standby 3kg mixed solution , soaked for 1 to 10 days and then filtered to obtain the coating solution for later use; put 1kg of gelatin into 1kg of water in a chemical glue tank to soak and dissolve into a gel solution, the temperature is 20 to 30°C, and the time is 0.5 to 2 hours; after soaking, use Circulate hot water to heat the glue tank. When the temperature of the glue is 40-80°C, vacuumize to remove the air bubbles in the glue. Then release the glue from the glue tank and filter it. Add an appropriate amount of food to the filtered glue Pigment and titanium dioxide, add 0.1-0.5% sodium lauryl sulfate at the same time, stir well and set aside; put the glue tank on the hollow capsule production line to dip in the glue, turn on the circulating wat...

Embodiment 2

[0019] Alcohol and acetone are mixed into a mixed solution for subsequent use, and its alcohol weight percentage is 35%, and acetone is 65% by weight; 1kg hydroxypropyl methylcellulose phthalate is dissolved in the above-mentioned standby 5kg mixed solution After soaking for 1-10 days, filter the coating solution for later use; put 1kg of gelatin into 2.5kg of water in a chemical glue tank and soak to dissolve into a gel solution, the temperature is 20-30°C, and the time is 0.5-2 hours; after soaking, Heat the glue tank with circulating hot water. When the temperature of the glue is 40-80°C, vacuumize to remove the air bubbles in the glue. Then release the glue from the glue tank and filter it. Add an appropriate amount of glue to the filtered glue Food coloring and titanium dioxide, add sodium lauryl sulfate of 0.1-0.5% of the weight of the glue at the same time, stir well and set aside; put the glue tank on the hollow capsule production line and dip it in glue, turn on the ci...

Embodiment 3

[0021] Alcohol and acetone are mixed into a mixed solution for subsequent use, and its alcohol weight percentage is 60%, and acetone is 40% by weight; 1kg hydroxypropyl methylcellulose phthalate is dissolved in the above-mentioned standby 8kg mixed solution , soaked for 1 to 10 days and then filtered to obtain the coating solution for later use; put 1kg of gelatin into 4kg of water in a chemical tank and soak to dissolve into a gel solution, the temperature is 20 to 30°C, and the time is 0.5 to 2 hours; after soaking, use Circulate hot water to heat the glue tank. When the temperature of the glue is 40-80°C, vacuumize to remove the air bubbles in the glue. Then release the glue from the glue tank and filter it. Add an appropriate amount of food to the filtered glue Pigment and titanium dioxide, add 0.1-0.5% sodium lauryl sulfate at the same time, stir well and set aside; put the glue tank on the hollow capsule production line to dip in the glue, turn on the circulating water te...

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Abstract

The invention relates to a production process of an enteric hollow capsule. The production process is characterized in that the enteric hollow capsule is formed by carrying out soling, coloring, sol dipping and drying on medicinal bone element gelatin which is used as a main raw material to obtain a gastric-soluble blank and coating and deciduating the gastric-soluble blank. The invention not only can be quickly dried and formed without generating soft and deformed capsules, but also can produce products with high surface smooth finish, small weight difference and high qualified rate.

Description

technical field [0001] The invention relates to a production process of hollow capsules, in particular to a production process of enteric-coated hollow capsules. Background technique [0002] Ordinary hollow capsules are filled with medicine to form a preparation, which dissolves in the stomach after oral administration, and exerts its medicinal effect after being absorbed in the small intestine. Because some medicines are irritating to the stomach, patients have side effects after taking them; and some medicines are easily degraded in case of gastric acid. Therefore, the above-mentioned medicines are not suitable for using common hollow capsule preparations. Enteric-coated hollow capsules do not dissolve in the stomach, and can only be dissolved after reaching the intestinal tract, thereby solving the problems of side effects and degradation of the above-mentioned drugs. In addition, enteric-coated hollow capsules can also be dissolved in the small intestine or colon accor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/38A61K47/32A61K47/02A61J3/07
Inventor 刘松林张志强
Owner ANHUI HUANGSHAN CAPSULE CO LTD
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