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Traditional Chinese medicine composition and application thereof in preparing medicine for preventing and treating porcine pseudorabies

A porcine pseudorabies and composition technology, which is applied in drug delivery, pharmaceutical formulations, antiviral agents, etc., can solve the complex, difficult, and complex problems of drug metabolism, achieve broad market prospects, reduce content, and improve vitality.

Active Publication Date: 2010-06-09
青岛海滨泰康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Foreign antiviral screening research is mainly to extract and separate active ingredients from natural organisms, and use a variety of molecular biological research methods (especially methods related to modern immunology experimental research) to study its molecular structure and antiviral molecular mechanism The relationship between them, so as to find effective antiviral drugs, which is still lacking in China
At the same time, due to the wide variety of viruses, simple structures, and complex mutations, the complex drug metabolism process after Chinese medicine enters the body, and the influence of Chinese medicine on the immune system after entering the body and the synergistic relationship between anti-viruses, etc. It is a complex and difficult task to design a suitable traditional Chinese medicine treatment for a virus

Method used

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  • Traditional Chinese medicine composition and application thereof in preparing medicine for preventing and treating porcine pseudorabies
  • Traditional Chinese medicine composition and application thereof in preparing medicine for preventing and treating porcine pseudorabies
  • Traditional Chinese medicine composition and application thereof in preparing medicine for preventing and treating porcine pseudorabies

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1 Observation of the efficacy of 15 kinds of single Chinese medicines against porcine pseudorabies virus in vitro

[0024] In this embodiment, 15 kinds of traditional Chinese medicines such as Astragalus, Radix Isatidis, Banzhilian, Senecio, Honeysuckle, Folium Folium, Forsythia, Cyperus, Houttuynia cordata, Didancao, wild chrysanthemum, Guanzhong, Chansu, Borneolum and Scutellaria baicalensis were selected. The efficacy of these 15 kinds of single traditional Chinese medicines against porcine pseudorabies virus was observed in vitro.

[0025] 1. Research on single traditional Chinese medicine

[0026] 1. Preparation of extracts of 15 kinds of single traditional Chinese medicines

[0027] Guanzhong extract: 50g of Guanzhong coarse powder was heated and refluxed with 80% alcohol to extract twice, each time 10 times the volume, 40min, the extracts were filtered while hot and combined, the crude extract was evaporated under reduced pressure, and the volume was adj...

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Abstract

The invention discloses a traditional Chinese medicine composition and an application thereof in preparing a medicine for preventing and treating porcine pseudorabies. The traditional Chinese medicine composition comprises 6-9 random Chinese herbal medicines of elephantopus scaber, echinacea, Chinese lobelia, radix isatidis, wild chrysanthemum flower, groundsel, weeping forsythia, cordate houttuynia or astragalus root, wherein the weight ratio of various Chinese herbal medicines of the elephantopus scaber to the echinacea to the Chinese lobelia to the radix isatidis to the wild chrysanthemum flower to the groundsel to the weeping forsythia to the cordate houttuynia to the astragalus root is 30:18:26:20:18:26:20:30. Under the guide of the basic theory of the traditional Chinese medicine, the invention screens out a traditional Chinese medicine composition by combining literature search and clinical experience. The Chinese herbal medicines in the composition respectively have the function of suppressing the multiplication of porcine pseudorabies viruses and have the functions of resisting the adsorption of the porcine pseudorabies viruses and directly killing the porcine pseudorabies viruses. The composition can enhance the immunity and the oxidation resistance of a rat, so that the traditional Chinese medicine composition can be used for preventing and treating the porcine pseudorabies and has extensive market prospect.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to the pig raising industry, in particular to a traditional Chinese medicine composition and its application in preparing medicines for preventing and treating swine pseudorabies. Background technique [0002] Porcine pseudorabies is an acute infectious disease caused by porcine pseudorabies virus (PRV), which can cause abortion, stillbirth and respiratory symptoms in pregnant sows. The disease has the characteristics of rapid transmission, high mortality, wide epidemic range, multiple transmission routes, and stubborn pathogens in pigs, which has caused huge losses to the pig industry every year. [0003] The development of therapeutic drugs for viral diseases is relatively slow, mainly because viruses are strictly parasitic and closely related to cells. After viruses infect cells, they enter cells and replicate in host cells using cellular enzyme systems; some viral nucleic acid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/08A61K9/10A61K9/14A61K9/16A61P31/20
Inventor 郭世宁仇微红吴鸿石达友孔德胜陈志虹魏光伟
Owner 青岛海滨泰康生物科技有限公司
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