New application of osthole for preventing and treating hyphantria cunea drury
A technology of osthole and American white moth, which is applied in the field of pesticides to achieve the effects of convenient storage and transportation, high stability and good water solubility
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Embodiment 1
[0014] Preparation of HP-β-CD inclusion complex
[0015] Take about 120g of HP-β-CD and place it in a three-neck flask, add 120ml of distilled water, and stir to dissolve the HP-β-CD. Add 2.5 g of osthole into the HP-β-CD solution, stir continuously at room temperature or 30°C (stirring speed is about 500r / min), continue inclusion for 24 hours or until the drug is completely dissolved, filter with suction, and spray the filtrate Dry or freeze-dry to obtain white loose granules (osthole HP-β-CD inclusion complex) and then add appropriate amount of excipients to prepare 2% osthole HP-β-CD inclusion complex granules.
Embodiment 2
[0017] Osthole Granules
[0018] 2% osthole HP-β-CD inclusion compound granule 250g, lactose 250g, starch 499g, 1% hydroxypropyl methylcellulose (K1000) solution appropriate amount, make granule, dry, granulate, test subpackage, each 100g bottle, 10 bottles in total.
Embodiment 3
[0020] Osthole Tablets
[0021] 2% osthole HP-β-CD inclusion complex granules 250g, lactose 250g, starch 494g, 1% hydroxypropylmethylcellulose (K1000) solution, make granules, dry, granulate, add magnesium stearate 5g, mixed granules, compressed into tablets, 1g / tablet, subpackaged for inspection, 100 tablets per bottle, 10 bottles in total.
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