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Improvement of completeness of intestinal barrier

A composition and energy technology, applied in the direction of allergic diseases, organic active ingredients, medical preparations containing active ingredients, etc.

Active Publication Date: 2010-04-14
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Prior art formulations are not optimal for improving barrier integrity

Method used

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  • Improvement of completeness of intestinal barrier
  • Improvement of completeness of intestinal barrier
  • Improvement of completeness of intestinal barrier

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Embodiment Construction

[0016] The present invention relates to nutritional compositions comprising:

[0017] a) EPA, DHA and ARA in which the content of long-chain polyunsaturated fatty acids containing 20 and 22 carbon atoms does not exceed 15% by weight of the total fat content; and

[0018] b) at least two different oligosaccharides, wherein the two different oligosaccharides have less than 90% monosaccharide unit homology.

[0019] Such a composition may advantageously be used in a method of stimulating intestinal barrier integrity comprising administering said composition to a mammal.

[0020] polyunsaturated fatty acid

[0021] The present inventors have surprisingly found that eicosapentaenoic acid (EPA, n-3), docosahexaenoic acid (DHA, n-3) and arachidonic acid (ARA, n-6) effectively reduce Intestinal tight junction permeability. Thus, the present composition, which is particularly suitable for improving intestinal barrier integrity, comprises EPA, DHA and ARA.

[0022] The inventors fo...

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Abstract

The invention relates to an improvement of completeness of an intestinal barrier, in particular to a method for exciting the barrier completeness of mammalian by applying a composition containing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA) and at least two different oligosaccharides to the mammalians.

Description

[0001] This application is a divisional application of the Chinese invention patent application with the application number 200480043417.0, the application date is June 22, 2004, and the invention title is "Improvement of Intestinal Barrier Integrity". technical field [0002] The present invention relates to methods of improving intestinal barrier integrity and compositions suitable for use in such methods. Background technique [0003] The gastrointestinal epithelium generally acts as a selective barrier - it allows the absorption of nutrients, electrolytes and water and prevents exposure to dietary and microbial antigens, including food allergens. The gastrointestinal epithelium restricts the entry of antigens into the systemic circulation, which can cause inflammatory reactions, such as anaphylaxis. Due to the increasing incidence of allergies, especially food allergies, (preventive) treatments for these diseases are being sought by many research groups. [0004] EP1272...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61P37/08A61P1/00A61K31/202A61K31/715A61K31/733A61K31/7068A61K31/7072A61K31/7076A61K31/708
Inventor E·A·F·文托L·E·M·威廉姆森M·A·克齐尔C·比尔曼B·斯坦尔
Owner NV NUTRICIA
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