A method for determining insulin sensitivity and glucose absorption

A technology for insulin sensitivity and insulin, applied in biochemical equipment and methods, microbial measurement/testing, application, etc., can solve problems such as neglect, and achieve the effect of high correlation of results and reliable insulin sensitivity

Inactive Publication Date: 2010-03-24
VERIDEX LCC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the OGIS method was originally model-based by fitting differential equations at individual time points, much information about the glucose and insulin profiles was ignored

Method used

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  • A method for determining insulin sensitivity and glucose absorption
  • A method for determining insulin sensitivity and glucose absorption
  • A method for determining insulin sensitivity and glucose absorption

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Embodiment 1

[0034] Research Design and Methods

[0035] S I AR a The A method involves using a simplified version of the classic minimal model of glucose metabolism, a method to describe the rate of glucose absorption during a meal with only two parameters, and an integration method to find optimal parameter values. A brief overview of these three components is provided below; details are described later.

[0036] mathematical model

[0037] The following mathematical model (described in more detail below) was used to describe glucose kinetics during the OGTT.

[0038] dG dt = R a exo ( t ) V G - S I ( G · I ...

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Abstract

The present invention encompasses a model-based method for determining insulin sensitivity and glucose absorption from oral glucose tolerance tests or mixed meals. The present invention has several advantages over current methods. The technique requires about four to six blood samples taken over about two to three hours following glucose ingestion and is therefore applicable to large-scale clinical trials. The analysis involves a reduced version of the classical minimal model, a method for describing glucose absorption using only two parameters, and an integral approach enabling the parametersto be obtained using simple algebra. The present method robustly identifies differences in insulin sensitivity in different patient types as well as improvements in insulin sensitivity arising from pharmaceutic therapy. In addition, insulin sensitivity measurements obtained with the present method are highly correlated with results from hyperinsulinemic clamps (r<2>>0.8). This method is thereforea practical and robust method for determining insulin sensitivity under physiologic conditions.

Description

[0001] Cross references to related patent applications [0002] This patent application requires the serial number of the name "A Method for Determining Insulin Sensitivity and Glucose Absorption (used for measuring insulin sensitivity and glucose absorption method)" submitted on April 20, 2007 and October 16, 2007 to be Priority of U.S. Provisional Patent Applications 60 / 912,998 and 60 / 980,230. Background technique [0003] Insulin resistance is a characteristic property of several metabolic diseases including obesity, type 2 diabetes and metabolic syndrome. Previously, several methods have been developed to measure insulin sensitivity based on fasting measurements, glucose tolerance test, or euglycemic-hyperinsulinemic clamp. See eg 5122362. [0004] Measuring insulin sensitivity in patients to quantify improvements in insulin sensitivity achieved with different therapies, identifying insulin sensitivity in individuals to further understand their pathophysiology and deter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G01N33/50G06F19/00
CPCC12Q1/006C12Q1/54G01N2800/044G01N2333/62G06F17/18G06F17/16G16H10/60G16H50/20G16H50/30A61B5/14532
Inventor D·C·波利多里
Owner VERIDEX LCC
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