Bupirimate microemulsion and preparation method thereof

Abstract

The invention discloses a bupirimate microemulsion and a preparation method thereof, wherein the bupirimate microemulsion comprises 5-25 percent of bupirimate, 0.5-15 percent of solvent, 0.5-10 percent of cosolvent, 1-5 percent of penetrant, 8-20 percent of surfactant, and the balance of water. The bupirimate microemulsion has simple and easy production process, high production efficiency, good drug effect and improved drug utilization ratio, overcomes a plurality of defects of the prior drug forms, reduces the pressure to the environment from organic solvents, avoids the dust pollution, and improves the product safety in producing, packaging, transporting and using processes.

Description

technical field [0001] The invention relates to a pyrithrimol sulfonate microemulsion and a manufacturing method thereof, belonging to the technical field of pesticide preparation processing. Background technique [0002] Acrimolsulfonate, chemical name: 5-butyl-2-ethylamino-6-methylpyrimidin-4-yl dimethylaminosulfate, English common name Bupirimate, molecular formula: C 13 h 24 N 4 o 3 S, molecular weight: 316.42, CAS number: 41483-43-6, light brown waxy solid, melting point 51-52°C, vapor pressure 0.067mPa (20°C). Solubility at room temperature: water 23mg / L (pH value 5.2), soluble in most organic solvents, hydrolyzed in case of dilute acid, unstable when stored above 37°C for a long time. The drug is a pyrimidine systemic fungicide, and its mechanism of action is an adenosine deaminase inhibitor. It has protective and therapeutic effects, and can be quickly absorbed by plant roots, stems, and leaves, and transported to various parts of the plant. Therefore, it is res...

AI Technical Summary

Problems solved by technology

There are some obvious deficiencies in the existing dosage forms, such as the presence of a large amount of organic solvents in the emulsifiable concentrate preparation, which is a potential pressure on the environment; wettable powders are prone to dust pollution during production, transportation, and use, and the processing process consumes energy. The particle size is large, which affects the absorption and conduction of the drug

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