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Method for preparing nanofibre membrane

A nanofiber membrane, chitosan technology, applied in fiber treatment, spinning solution preparation, medical science and other directions, can solve problems such as no reports, achieve good biocompatibility and reduce platelet aggregation.

Inactive Publication Date: 2010-02-03
JIANGNAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There have been reports on the preparation of antibacterial silver / chitosan nanofiber membranes, but the preparation method of curcumin / chitosan nanofiber membranes has not yet been reported.

Method used

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  • Method for preparing nanofibre membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) preparation mass concentration is the acetic acid aqueous solution of 3%, with relative molecular weight being 300,000, the chitosan that deacetylation degree is 85% is dissolved in the acetic acid aqueous solution, is configured into the chitosan acetic acid that mass concentration is 60g / L solution.

[0027] (2) Dissolve curcumin in absolute ethanol, stir and dissolve, and prepare a curcumin absolute ethanol solution with a curcumin concentration of 20 g / l.

[0028] (3) Chitosan acetic acid solution and curcumin absolute ethanol solution were mixed at a volume ratio of 5:1 to prepare an electrospinning solution with a concentration of 5% (w / v).

[0029] (4) The prepared spinning solution was injected into the syringe of the electrospinning device, and the inner diameter of the nozzle was 0.7 mm. The electrospinning process conditions are as follows: the voltage is 15kV, the flow rate is 0.05ml / h, and the receiving distance is 15cm.

[0030] (5) Adopting a drum c...

Embodiment 2

[0033] (1) preparation mass concentration is the acetic acid aqueous solution of 3%, with relative molecular weight being 200,000, the chitosan that deacetylation degree is 95% is dissolved in the acetic acid aqueous solution, is configured into the chitosan acetic acid that mass concentration is 50g / l solution.

[0034] (2) Dissolve curcumin in absolute ethanol, stir and dissolve, and prepare curcumin absolute ethanol solution with a curcumin concentration of 25 g / l.

[0035] (3) Chitosan acetic acid solution and curcumin absolute ethanol solution were mixed at a volume ratio of 6:1 to prepare an electrospinning solution with a concentration of 6% (w / v).

[0036] (4) The prepared spinning solution was injected into the syringe of the electrospinning device, and the inner diameter of the nozzle was 0.8 mm. The electrospinning process conditions are as follows: the voltage is 18kV, the flow rate is 0.08ml / h, and the receiving distance is 17cm.

[0037] (5) Using a flat plate ...

Embodiment 3

[0040] (1) preparation mass concentration is the acetic acid aqueous solution of 4%, with relative molecular weight being 400,000, the chitosan that deacetylation degree is 80% is dissolved in the acetic acid aqueous solution, is configured into the chitosan acetic acid that mass concentration is 55g / l solution.

[0041] (2) Dissolving curcumin in absolute ethanol, stirring and dissolving, and preparing a curcumin absolute ethanol solution with a curcumin concentration of 30 g / l.

[0042] (3) Chitosan acetic acid solution and curcumin absolute ethanol solution were mixed at a volume ratio of 8:1 to prepare an electrospinning solution with a concentration of 6% (w / v).

[0043] (4) The prepared spinning solution was injected into the syringe of the electrospinning device, and the inner diameter of the nozzle was 0.9mm. The electrospinning process conditions are as follows: the voltage is 18kV, the flow rate is 0.08mL / h, and the receiving distance is 18cm.

[0044] (5) Using a ...

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Abstract

The invention discloses a method for preparing a nanofibre membrane, belonging to a technique for preparing a nanofibre compound membrane. The method comprises the following steps: preparing curcuminethanol solution and chitosan acetum, mixing the curcumin ethanol solution and the chitosan acetum by the volume ratio thereof to prepare spinning solution which is injected into an injector of an electrostatic spinning device for electrostatic spinning to form a compound nanofibre membrane and to obtain a curcumin / chitosan nanofibre membrane of antibacterial property, wherein the diameter of thecurcumin / chitosan nanofibre membrane is 200-400 nm. The invention has the advantages that the preparation process is simple, the prepared membrane material heals wound, has broad spectrum bactericidalproperty and has higher bacterial inhibition rate to colibacillus and staphylococcus aureus for 24h.

Description

technical field [0001] The invention relates to a preparation technology of nanocomposite fibers, in particular to a preparation method of a curcumin / chitosan nanofiber film with antibacterial properties. Background technique [0002] Various nanofiber films can be prepared by electrospinning technology. Although a single chitosan film has good biocompatibility, antibacterial properties, and certain hemostatic and wound healing effects, its broad-spectrum antibacterial properties are poor, which greatly limits the application range of chitosan. [0003] Chitosan widely exists in the shells of arthropods such as shrimps and crabs, and its annual synthesis amount in nature is second only to cellulose, so it has a wide range of uses. Deacetylated chitosan is obtained after deacetylation of chitosan, which has good film-forming properties, anti-infection effect, and promotes wound healing. [0004] Curcumin is an active ingredient in the rhizome of turmeric, a commonly used tr...

Claims

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Application Information

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IPC IPC(8): D04H3/16D01D5/00D01D1/02A61L15/28A61L15/20A61L15/46A61L15/44
Inventor 王鸿博高卫东陈艳陈建强徐亮
Owner JIANGNAN UNIV
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