Tiny vein injection drug delivery system on body surface of experimental animal

Abstract

The invention relates to a drug delivery system for experimental animals, in particular to a tiny vein injection drug delivery system on body surfaces of experimental animals. The system comprises a fixed chamber 5 for experimental animals, a simple desk type magnifying glass, a vascular clamp 7 and an injector 1 with a superfine injection needle 2, wherein the fixed chamber 5 for experimental animals fixes experimental animals; the vascular clamp 7 is clamped above injection blood vessel; the injector 1 is connected with the superfine injection needle 2; the simple desk type magnifying glassis arranged above vein injection operation, and the injection can be carried out; and component parts of the device can be used solely or be in arbitrarily combined use according to actual operation requirement. The invention has the beneficial effect that the tiny vein injection process of experimental animals is more accurate, efficient, convenient and fast.

Description

Technical field [0001] The patent of the present invention relates to a drug delivery device for experimental animals, in particular to a drug delivery device for micro-vein injection on the body surface of experimental animals. Background technique [0002] Microvenous administration on the body surface is a commonly used method of drug administration in experimental animals, but due to its high technical difficulty, the success rate in actual operation is very low, especially in the long-term administration process, often resulting in failure of the entire experiment due to the failure of the administration operation. Finish. [0003] At present, the microvenous administration method of experimental animals is mostly manually operated. The traditional operation process is to place the mouse in an upside-down beaker, expose the tail of the mouse to the outside of the beaker, and inject the drug into the tail vein of the mouse with a 1 ml syringe. When using this method to ...

AI Technical Summary

Problems solved by technology

When using this method to operate, the experimental mice cannot be fixed well, and the experimental animals are always in a state of struggle, which often leads to failure to insert the needle or the needle punctures the blood vessel after the animal struggles, resulting in the failure of the experiment

In addition, when using this method for tail vein injection, because the tail vein blood vessels of mice are relatively small and difficult to fill, the needle insertion is inaccurate, or the resistance during injection after needle insertion is relatively high, resulting in local swelling and whitening, and the injection fails. low rate

[0004] Patent CN: 200810018231 Use a special rod clamp to fix the hand shape of the operator when injecting the tail vein of mice. The position and depth of the needle insertion are consistent with the hand shape for each subsequent injection, but due to individual differences in mice Large size, short tail, uneven thickness, using the same needle insertion depth and angle, cannot meet the actual needs of all experimental mice, so the effect of this patent is not ideal in actual operation, and the application is limited

[0005] It is currently reported that the needles of the syringes used are relatively thick, and it is difficult to penetrate into the small veins of experimental animals, or even if they penetrate into the small veins, because the needles are too thick, it is easy to puncture the blood vessel wall and cause the liquid to leak out, resulting in injection failure.

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