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Pharmaceutical composition for treating senile skin pruritus and preparation method thereof

A skin pruritus and age-related technology, applied in drug combinations, skin diseases, pharmaceutical formulas, etc., can solve the problems of poor treatment effect and easy recurrence, and achieve the advantages of simple and feasible preparation process, high cure rate and good curative effect Effect

Active Publication Date: 2010-01-20
广西维威制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide senile skin pruritus patients with a highly targeted, high cure rate, safe, non-toxic and side effects, cheap and effective medicine, so as to solve the problem of poor clinical treatment effect and easy recurrence of elderly patients. Technical problems of pruritus vulgaris

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: Capsules

[0037] 1. According to the composition and weight ratio of the prescription, take the raw material medicine and remove impurities, then weigh it for later use. 200 grams of astragalus, 200 grams of rehmannia, 100 grams of angelica, 100 grams of white peony, 100 grams of safflower, 100 grams of crocodile, 150 grams of salvia, 120 grams of nepeta, 150 grams of wind, 200 grams of white moss bark, and 100 grams of white tribulus 100 grams of licorice.

[0038] 2. Add 12 times the amount of water to distill angelica and Nepeta, collect volatile oil, and use a colloid mill to carry out inclusion of volatile oil and β-CD at a ratio of 1:8. The inclusion temperature is 30-50°C, and the inclusion time is about 30 Minutes, let it stand for 24 hours, suction-filtered to obtain the clathrate, then dried at a low temperature of 40-70°C, pulverized and passed through an 80-mesh sieve to obtain the β-CD clathrate A for use.

[0039] 3. Salvia miltiorrhiza, w...

Embodiment 2

[0043] Embodiment 2: tablet

[0044] 1. According to the composition and weight ratio of the prescription, take the raw material medicine and remove impurities, then weigh it for later use. 150 grams of astragalus, 150 grams of rehmannia, 80 grams of angelica, 80 grams of white peony root, 80 grams of safflower, 60 grams of scrophulariaceae, 100 grams of salvia miltiorrhiza, 90 grams of nepeta, 100 grams of windproof, 150 grams of white moss bark, 60 grams of white tribulus , licorice 60 grams.

[0045] 2. Add 12 times the amount of water to Distill Angelica and Schizonepetae, collect volatile oil, and use a colloid mill to carry out inclusion of volatile oil and β-CD at a ratio of 1:6. The inclusion temperature is 30-50°C, and the inclusion time is about 30 Minutes, let it stand for 24 hours, suction-filtered to obtain the clathrate, then dried at a low temperature of 40-70°C, pulverized and passed through an 80-mesh sieve to obtain the β-CD clathrate A for use.

[0046]3. ...

Embodiment 3

[0050] Embodiment 3: Granules

[0051] 1. According to the composition and weight ratio of the prescription, take the raw material medicine and remove impurities, then weigh it for later use. 250 grams of astragalus, 250 grams of rehmannia, 120 grams of angelica, 120 grams of white peony root, 120 grams of safflower, 120 grams of crocodile, 180 grams of salvia miltiorrhiza, 150 grams of nepeta, 180 grams of windproof, 250 grams of white moss bark, 120 grams of white tribulus 120 grams of licorice.

[0052] 2. Add 12 times the amount of water to distill angelica and Nepeta, collect volatile oil, and use a colloid mill to carry out inclusion of volatile oil and β-CD at a ratio of 1:10. The inclusion temperature is 30-50°C, and the inclusion time is about 30 Minutes, let it stand for 24 hours, suction-filtered to obtain the clathrate, then dried at a low temperature of 40-70°C, crushed through an 80-mesh sieve, and obtained the β-CD clathrate A for use.

[0053] 3. Salvia milti...

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Abstract

The invention relates to a pharmaceutical composition for curing senile skin pruritus and a preparation method thereof. The pharmaceutical composition comprises the following components: astragalus root, prepared rehmannia root, Chinese angelica root, white peony root, safflower, figwirt root, red sange root, schizonepta, ledebouriella root, cortex dictamni radicis, Tribulus terrestris and liquorice. The preparation method comprises the following steps: distilling the Chinese angelica root and the schizonepta by water vapor to collect volatile oil, and carrying out inclusion by beta-CD; crushing the red sange root, the ledebouriella root and the cortex dictamni radicis into coarse powder, adding 70-90 percent of ethanol into coarse powder to extract twice, and merging and concentrating the extracting solutions into thick paste; mixing the rest medicinal herbs with the dregs obtained after distillation and the dregs obtained after ethanol extraction, then decocting the mixture in water and extracting, and then concentrating the decoction into thick paste; and adding the conventional preparation auxiliary materials and evenly mixing to prepare various oral preparations such as capsules, tablets, granules, and the like. The preparation process is simple and convenient, and the raw materials are all pure natural Chinese herbal medicines, therefore, the pharmaceutical composition has no toxic side effect, has good therapeutic effect for treating the yin-deficiency and wind-dryness type pruritus cutanea, especially for the senile skin pruritus and also has the advantages of fast effect, strong pointedness and high curative ratio.

Description

technical field [0001] The invention relates to a medicine combination for treating skin pruritus and a preparation method thereof, in particular to a medicine combination for treating senile skin pruritus and a preparation method thereof. Background technique [0002] Senile pruritus is a relatively common skin disease among elderly patients. It is called "wind pruritus" in traditional Chinese medicine. A skin disease with secondary skin lesions. The disease is mostly limited to one place at the beginning, and then gradually spread to most of the body, such as the trunk, limbs and even the whole body. The itching is sometimes mild and sometimes severe. The short one is only a few minutes, and the elderly can last for several hours, even restless all night. It is difficult to stop and makes the elderly suffer unbearably. Continuous and intense scratching can cause scratches on the affected area, bloody scabs, and paroxysmal itching, especially at night, which affects sleep...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P17/04
Inventor 凌远标
Owner 广西维威制药有限公司
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