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In-situ fiber-forming strengthened degradable medical elastic composite material and preparation method thereof

An elastic composite material, in-situ fiber-forming technology, applied in medical science, catheters, prostheses, etc., can solve the problems of high production cost, poor mechanical properties, and increased surgical risks for patients

Active Publication Date: 2010-01-13
ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, non-degradable elastomers mainly include silicone rubber medical elastomers, polyurethane medical elastomers, etc. Non-degradable medical elastomers have many shortcomings in clinical applications. At the same time, the risk of surgery is increased. In addition, due to the poor biocompatibility of most non-degradable materials, foreign body reactions often occur after implantation in the body, causing a series of complications.
Degradable elastomers are mainly divided into polyether ester bioelastomers, polypeptide bioelastomers, hydrogels and polyester bioelastomers. Although biodegradable medical elastomers have good biocompatibility, the production High cost, complex processing conditions, and poor mechanical properties limit clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Premix polyglycolic acid and poly(L-lactide-ε-caprolactone) at a mass ratio of 5 / 95, and extrude using a single-screw extruder in a nitrogen atmosphere. The temperature of the extruder is set to: (I) zone 220°C, (II) zone 240°C, (III) zone 230°C, (IV) zone 230°C; extruder screw speed is 10r / min; Traction speed traction, control the stretch ratio (die diameter / spline diameter) to 3, and quench with water during the traction process to obtain polyglycolic acid in-situ fiber-forming reinforced poly(L-lactide-ε-caprolactone) composite material. Poly(L-lactide-ε-caprolactone) weight average molecular weight (M w ) is 155,000, and the molar percentage of ε-caprolactone units is 15%; the intrinsic viscosity [η] of polyglycolic acid is 1.5 g / dl. Test result shows: poly(L-lactide-ε-caprolactone) tensile strength is 28.2MPa; The tensile strength of gained polyglycolic acid / poly(L-lactide-ε-caprolactone) is 33.2MPa, the elongation at break is 590%.

Embodiment 2

[0020]Premix polyglycolic acid and poly(L-lactide-ε-caprolactone) at a mass ratio of 10 / 90, and extrude using a single-screw extruder in a nitrogen atmosphere. The temperature of the extruder is set to: (I) zone 220°C, (II) zone 240°C, (III) zone 230°C, (IV) zone 230°C; extruder screw speed is 20r / min; Traction speed traction, control the stretch ratio (die diameter / spline diameter) to 3, and quench with water during the traction process to obtain polyglycolic acid in-situ fiber-forming reinforced poly(L-lactide-ε-caprolactone) composite material. Among them, poly(L-lactide-ε-caprolactone) weight average molecular weight (M w ) is 284,000, and the molar percentage of ε-caprolactone units is 18%; the intrinsic viscosity [η] of polyglycolic acid is 2.1 g / dl. Test result shows: poly(L-lactide-ε-caprolactone) tensile strength is 25.1MPa; The tensile strength of gained poly(L-lactide-ε-caprolactone) / polyglycolic acid is 33.4MPa, the elongation at break is 568%.

Embodiment 3

[0022] Premix polyglycolic acid and poly(L-lactide-ε-caprolactone) at a mass ratio of 10 / 90, and extrude using a single-screw extruder in a nitrogen atmosphere. The temperature of the extruder is set to: (I) zone 220°C, (II) zone 240°C, (III) zone 230°C, (IV) zone 230°C; extruder screw speed is 25r / min; Traction speed traction, control the stretching ratio (die diameter / spline diameter) to 4, and quench with water during the traction process to obtain in-situ fiber-forming poly(L-lactide-ε-caprolactone) with polyglycolic acid composite material. Among them, poly(L-lactide-ε-caprolactone) weight average molecular weight (M w ) is 403,000, the molar percentage of ε-caprolactone units is 22%; the intrinsic viscosity [η] of polyglycolic acid is 2.6g / dl. Test result shows: poly(L-lactide-ε-caprolactone) tensile strength is 26.1MPa; The tensile strength of gained poly(L-lactide-ε-caprolactone) / polyglycolic acid is 36.4MPa, the elongation at break is 572%.

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Abstract

The invention discloses an in-situ fiber-forming strengthened degradable medical elastic composite material and a preparation method thereof. The composite material is prepared by premixing polyglycolic acid or poly-(L-lactic acid) and poly-(L-lactide-tao-caprolactone) by a weight ratio of 20:80 to 5:95 in an inert gas atmosphere; extruding the mixture in a plastic extruder with a screw rotation speed of 10-80 r / min; hauling the extruded mixture by a hauling machine at a hauling speed of 1-30 m / min; controlling a die diameter / a spline diameter to be 1-6; and quenching with water in a hauling process. The composite material can be fully biologically degraded, has obviously improved tensile strength, enables fused mass to have little abrasion on the inner wall of an equipment cavity in the processing process and can be used in medical fields, such as degradable catheters, elastic fascia, artificial skin, and the like.

Description

technical field [0001] The invention belongs to the field of polymer biomedical materials. Specifically, the present invention relates to a kind of poly(L-lactide-ε) reinforced by polyglycolic acid [poly(glycolic acid), PGA] or poly(L-lactic acid) [poly(L-lactic acid), PLLA] -caprolactone) [poly(L-lactide-co-ε-caprolactone), PLLCA] in-situ fiber-forming degradable medical elastomer composite material preparation method. Background technique [0002] With the continuous development of clinical medicine, biomedical elastomer materials have been more and more widely used. At present, the reported medical elastomers are mainly divided into two categories: degradable medical elastomers and non-degradable elastomers. Among them, non-degradable elastomers mainly include silicone rubber medical elastomers, polyurethane medical elastomers, etc. Non-degradable medical elastomers have many shortcomings in clinical applications. At the same time, the risk of surgery is increased. In ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/12A61L29/14A61L27/48A61L27/58A61L27/60A61L29/06A61L27/18
Inventor 王连嵩熊成东陈和春庞秀炳吴侃李庆吴龙华陈庆
Owner ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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