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Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

A therapeutic agent and surgery technology, applied in the field of prognostic therapeutic agents, can solve the problem of not knowing AS-013 and so on

Active Publication Date: 2012-03-21
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] As mentioned above, AS-013 has not been known to be effective as a therapeutic agent to improve the prognosis of lower limb amputation surgery performed due to severe peripheral arterial occlusion

Method used

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  • Therapeutic agent for ameliorating prognosis after lower limb amputation surgery
  • Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0033] Production Example 1: Production method of AS-013 liposome preparation

[0034] Add 10g of refined soybean oil and 1.2g of refined egg yolk lecithin to 500μg of AS-013, use a homogenizer at 90°C and heat at 90°C to dissolve, add 2.5g of Japanese Pharmacopoeia glycerin and 90mL of distilled water for injection It was coarsely emulsified with a homogenizer at 90°C, and then emulsified with a Manton-Gaulin type homogenizer to prepare a fat emulsion (liposome preparation).

manufacture example 2

[0035] Manufacturing example 2: Manufacturing method of AS-013 liposome preparation for injection

[0036] An appropriate amount of oleic acid and sodium hydroxide were added to the liposome preparation obtained in Production Example 1, and the final concentration of AS-013 was 5 μg / mL to obtain an injection preparation.

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PUM

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Abstract

Disclosed is a therapeutic agent for ameliorating the prognosis after lower limb amputation surgery which is induced by severe peripheral arterial disease. The therapeutic agent comprises a prostaglandin E1 (PGE1) derivative shown by the formula (I) (AS-013) as an active ingredient. Preferably, the therapeutic agent takes a dosage form of a preparation for intravenous or local administration. More preferably, the preparation for injection takes a dosage form of a liposome preparation having the active ingredient AS-013 embedded in a lipid particle.

Description

【Technical Field】 [0001] The present invention relates to a therapeutic agent for improving the prognosis of lower extremity amputation surgery. Specifically, the present invention relates to a prostaglandin E1 derivative AS-013 as an active ingredient to improve severe peripheral artery occlusion (severe peripheral artery occlusion). arterial disease)) and a prognostic therapeutic agent for lower limb amputation. 【Background technique】 [0002] In recent years, due to the westernization of diet, more and more patients have developed arteriosclerosis obliterans due to arteriosclerosis or diabetes. With arteriosclerosis obliterans, the blood flow impairment is aggravated, leading to severe pain, intractable ulcers, and necrosis (severe lower limb ischemia), daily life becomes difficult, and quality of life decreases. For patients with severe arteriosclerosis obliterans, if appropriate treatment is not taken and they are left unattended, they may need to amputate their legs and to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P43/00A61P9/10A61K31/5575
CPCA61K31/5575A61P9/10A61P43/00
Inventor 水岛裕村上雅弘
Owner BEIJING TIDE PHARMA
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