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Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

A therapeutic agent and surgery technology, applied in the field of prognostic therapeutic agents, can solve the problem of not knowing AS-013 and so on

Active Publication Date: 2010-01-06
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] As mentioned above, AS-013 has not been known to be effective as a therapeutic agent to improve the prognosis of lower limb amputation surgery performed due to severe peripheral arterial occlusion

Method used

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  • Therapeutic agent for ameliorating prognosis after lower limb amputation surgery
  • Therapeutic agent for ameliorating prognosis after lower limb amputation surgery

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0033] Production Example 1: Production method of liposome preparation of AS-013

[0034] Add 10g of refined soybean oil and 1.2g of refined egg yolk lecithin to 500μg of AS-013, heat and dissolve with a homogenizer at 90°C, add 2.5g of Japanese Pharmacopoeia glycerin and 90mL of distilled water for injection , coarsely emulsified with a homogenizer at 90° C., and further emulsified with a Manton-Gaulin type homogenizer to prepare a fat emulsion (liposome preparation).

manufacture example 2

[0035] Production Example 2: Production method of injection formulation of liposome formulation of AS-013

[0036] An appropriate amount of oleic acid and sodium hydroxide was added to the liposome preparation obtained in Production Example 1 to prepare a final concentration of AS-013 of 5 μg / mL to obtain a preparation for injection.

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Abstract

Disclosed is a therapeutic agent for ameliorating the prognosis after lower limb amputation surgery which is induced by severe peripheral arterial disease. The therapeutic agent comprises a prostaglandin E1 (PGE1) derivative shown by the formula (I) (AS-013) as an active ingredient. Preferably, the therapeutic agent takes a dosage form of a preparation for intravenous or local administration. More preferably, the preparation for injection takes a dosage form of a liposome preparation having the active ingredient AS-013 embedded in a lipid particle.

Description

【Technical field】 [0001] The present invention relates to the therapeutic agent that improves the prognosis of lower limb amputation operation, specifically, the present invention relates to containing prostaglandin E1 derivative AS-013 as active ingredient, improves the disease caused by severe peripheral arterial occlusion (severe peripheral arterial occlusion (severe peripheral arterial occlusion) A therapeutic agent for the prognosis of lower extremity amputations performed for arterial disease). 【Background technique】 [0002] In recent years, the number of patients with arteriosclerosis obliterans due to arteriosclerosis or diabetes has increased due to Westernization of diet. Obliterative arteriosclerosis will lead to aggravated blood flow disturbances, resulting in severe pain, intractable ulcers, and necrosis (severe lower extremity ischemia), daily life becomes difficult, and quality of life deteriorates. For patients with severe arteriosclerosis obliterans, if ap...

Claims

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Application Information

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IPC IPC(8): A61K31/5575A61P43/00A61P9/10
CPCA61K31/5575A61P9/10A61P43/00
Inventor 水岛裕村上雅弘
Owner BEIJING TIDE PHARMA
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