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Wintergreen barberry root suppository and preparation method thereof

A technology of suppositories and Coptis chinensis, applied in suppository delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2013-02-27
蒋伟哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The anal suppository made from Litectin can treat internal hemorrhoids and rectal inflammation; the vaginal suppository can be used to treat vaginitis and acute vaginitis, and there is no suppository that uses Litectin as a drug to treat the above diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 270 g of the extract of Litectin, pulverize the extract, pass through a 200-mesh sieve, and make 250 g of powder. After heating and melting 500g of semi-synthetic fatty acid lipid, add the extract powder of Litectinus chinensis, stir to mix evenly, pour it into the plug mold after cooling slightly, take it out after cooling. The resulting product is 500 anal suppositories.

Embodiment 2

[0020] Weigh 100 g of the extract of Litectin, pulverize the extract, pass through a 200-mesh sieve, and make 80 g of powder. After heating and melting 370g of semi-synthetic fatty acid lipid, add the extract powder of Litectinus chinensis, stir to mix evenly, pour it into the plug mold after cooling slightly, and take it out after cooling. The resulting product is 500 anal suppositories.

Embodiment 3

[0022] Weigh 370 g of the extract of Litectin, pulverize the extract, pass through a 200-mesh sieve, and make 350 g of powder. After heating and melting 500g of semi-synthetic fatty acid lipid, add the extract powder of Litectinus chinensis wrapped in ethyl cellulose, stir to make it evenly mixed, cool slightly, pour it into a bolt mold, and take it out after cooling. The resulting product is 500 anal suppositories.

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PUM

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Abstract

The invention relates to a wintergreen barberry root suppository and a sustained and controlled release wintergreen barberry root suppository, belonging to the technical field of pharmaceuticals. The preparation is prepared by the following steps: using wintergreen barberry roots as raw materials and carrying out steps of pulverization, reflux extraction, decompression concentration, pH regulation, and the like to obtain a tan wintergreen barberry root extract; using the tan wintergreen barberry root extract as an active pharmaceutical ingredient and adding a fat-soluble suppository matrix or sustained and controlled release macromolecular materials to prepare the wintergreen barberry root suppository or the sustained and controlled release wintergreen barberry root suppository. The preparation has obvious anti-inflammatory effect and can be prepared into a rectal suppository used for treating internal hemorrhoids and rectal inflammations and a vaginal suppository used for treating vaginitis and acute vaginitis according to different application and administration routes.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to an anal suppository with remarkable anti-inflammatory effect, which can be used for treating internal hemorrhoids and rectal inflammation, and a vaginal suppository for treating vaginitis and acute vaginitis. Background technique: [0002] Corydalis saxicola Bunting is a plant of the genus Corydalis in the family Papaveraceae. It is a characteristic medicinal material in Guangxi Zhuang Autonomous Region. Research has confirmed that ten crystalline chemical components have been isolated from Corydalis saxicola: Carvitin and dehydrocarvitin. (Petidine), dextral basaline, dextral tetrahydropalmatine, berberine, dextrorotary 13-β-hydroxypapaverine, L-sculetine, corydaline, chelerythrine, Proto-opioid etc. The medicinal materials are included in the "Guangxi Standards of Chinese Materia Medica", and the main functions and indications are recorded: clearing away dampnes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61K36/66A61P15/02A61P9/14A61P1/00
Inventor 蒋伟哲黄增琼黄兴振黄敏巫世红吕聪巫玲玲
Owner 蒋伟哲
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