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Novel medicinal use of active parts of abelmoschus manihot general flavones

The technology of effective parts and hollyhock flowers is applied in the field of biomedicine, and can solve the problems of long course of treatment and large dosage, and achieve the effect of simple and easy treatment.

Active Publication Date: 2010-01-06
HANGZHOU CONBA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used Chinese patent medicines in clinic, such as Sanjin Tablets, Yinhua Biyanling Tablets, etc., have relatively good curative effects, but there are also shortcomings, such as large dosages and long courses of treatment
[0006] Chinese patent 93110506.4 discloses a drug for treating primary glomerular disease and chyluria using the crude extract of marshmallow flower as the active ingredient; Chinese patent 200410035741 .X provides a method for extracting and preparing total flavonoids from hollyhock flowers; Chinese patent 200610097615.6 discloses a total flavonoids extract from hollyhock flowers for the preparation of medicines for treating nephritis, but there is no treatment of urinary tract infection with total flavonoids from hollyhock flowers , including literature reports of cystitis and urethritis

Method used

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  • Novel medicinal use of active parts of abelmoschus manihot general flavones
  • Novel medicinal use of active parts of abelmoschus manihot general flavones
  • Novel medicinal use of active parts of abelmoschus manihot general flavones

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1 Preparation of effective fractions of total flavonoids of hollyhock flower

[0016] Add an appropriate amount of 80% ethanol to the hollyhock flower, extract once, extract for 2 hours, combine the extracts, filter, concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 at 60°C, add an appropriate amount of water to sink for 24 hours, and filter with suction. Concentrate to the corresponding volume, pass through a macroporous adsorption resin column, use alcohol-water gradient elution, water elution 3 column volumes, 10% and 30% ethanol each elution 3 column volumes, 70% ethanol elution 1 column volume . The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract of the marshmallow flower, and the total flavonoid content is 65%.

Embodiment 2

[0017] Example 2 Preparation of Capsules of Effective Fractions of Total Flavonoids of Melhock Flowers

[0018] Take 250g of the extract of effective fractions of total flavonoids from hollyhock flowers, 50g of magnesium stearate, pass through an 80-mesh sieve, mix well, dry granulate, fill 1000 capsules, and each capsule contains 250mg of effective fractions from total flavonoids from hollyhock flowers. Usage: 2 capsules each time, three times a day.

Embodiment 3

[0019] Example 3 The preparation of the active fraction tablet of total flavonoids of hollyhock flower

[0020] Take 250g of the effective part extract of total flavonoids of hollyhock flower and 45g of microcrystalline cellulose, mix well, wet granulate with ethanol, and pass through a 20-mesh sieve. Add 5 g of magnesium stearate, mix evenly, and press to form 1000 tablets with a tablet weight of 0.3 g / tablet, each containing 250 mg of active parts of total flavonoids from hollyhock flowers. Usage: 2 tablets each time, three times a day.

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Abstract

The invention discloses a novel medicinal use of the active parts of abelmoschus manihot general flavones, in particular use of the active parts of abelmoschus manihot general flavones in the preparation of medicaments for treating urinary tract infection including cystitis and urethritis. Abelmoschus manihot has the effects of disinhibiting water, dissipating stasis, dispersing swelling, detoxification and relieving common symptoms of urinary tract infection, such as frequent micturition, urgent urination, odynuria and unwell micturition. The active parts of abelmoschus manihot general flavones have excellent inhibiting effects on staphylococcus aureus, staphylococcus epidermidis and other gram-positive bacteria and negative bacteria, and have anti-inflammatory and pain-relieving effects and an obvious diuretic effect. Therefore, the active parts of abelmoschus manihot general flavones have excellent effects on the treatment of urinary tract infection, particularly chronic recurrent urinary tract infection.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and in particular refers to a new drug application of effective parts of total flavonoids of hollyhock flowers, specifically the application in the preparation of medicines for treating urinary tract infection, including the preparation of effective parts of total flavonoids of hollyhock flowers in the preparation and treatment of cystitis and The application of the urethritis medicine includes the application of the pharmaceutical composition with the active ingredient of the total flavonoids of the marshmallow flower in the preparation of the medicine for treating urinary tract infection. Background technique [0002] Urinary tract infection (UTI, referred to as urinary infection) is a common clinical disease and frequently-occurring disease. It is an inflammatory lesion caused by pathogenic bacteria invading the urinary tract, including cystitis and urethritis. According to the nature of inf...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P13/02A61P13/10A61K133/00
Inventor 张玲凌沛学尚立霞
Owner HANGZHOU CONBA PHARMA
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