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Method for preparing high-strength hydroxylapatite and chitosan three-dimensional composite rod material

A hydroxyapatite, three-dimensional composite technology, applied in medical science, surgery, etc., can solve problems such as atrophy, affecting the activity and proliferation of seed cells or growth factors, secondary fractures, etc., and achieve the effect of size reduction

Inactive Publication Date: 2009-12-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many biomaterials prepared from metal and polymer materials are used for the treatment of orthopedic diseases, but these materials have significant defects, such as: the mechanical compatibility of metal materials with bone tissue is not good, resulting in loosening or Dislocation; produce stress shielding effect, resulting in fracture loosening or bone atrophy, can not form callus at the fracture site, prone to secondary fractures; the release of metal ions will cause allergic reactions; metal materials require secondary surgery to remove the implant; current clinical Acidic substances are released when the polymer materials used degrade, causing non-bacterial inflammatory responses and affecting the activity and proliferation of seed cells or growth factors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Weigh Ca(NO 3 ) 2 4H 2 O 2.35 g and NaH 2 PO 4 2H 2 O 0.93g, join 400ml volume fraction and be in the dilute acetic acid aqueous solution of 2%, stir 10min, form the hydroxyapatite precursor solution;

[0018] 2) Add 20 g of chitosan powder to the hydroxyapatite precursor solution, stir for 1 h, and leave the obtained mixed solution to defoam for 24 h;

[0019] 3) Take a small amount of chitosan solution and inject it into the mold to form a layer of inner film, then inject the mixed solution in step 2) into the mold, and then put the mold filled with the mixed solution into a 5% NaOH coagulation solution by mass fraction , solidified for 6 hours, demolded to obtain a hydroxyapatite / chitosan composite gel rod, and washed the composite gel rod with distilled water until neutral;

[0020] 4) Measure 0.5ml of glutaraldehyde aqueous solution with a mass fraction of 25% and add it to 1000ml deionized water, then put hydroxyapatite / chitosan composite gel rods (10 pie...

Embodiment 2

[0025] 1) Weigh CaCl 2 2.22g and KH 2 PO 4 1.62 g was added to 400 ml of dilute acetic acid aqueous solution with a volume fraction of 2%, and stirred for 10 min to form a hydroxyapatite precursor solution;

[0026] 2) Add 20 g of chitosan powder to the hydroxyapatite precursor solution, stir for 1 h, and leave the obtained mixed solution to defoam for 24 h;

[0027] 3) Take a small amount of chitosan solution and inject it into the mold to form a layer of inner film, then inject the mixed solution in step 2) into the mold, and then put the mold filled with the mixed solution into the KOH coagulation solution with a mass fraction of 5%. , solidified for 12 hours, demolded to obtain a hydroxyapatite / chitosan composite gel rod, and washed the composite gel rod with distilled water until neutral;

[0028] 4) Measure 2ml of glutaraldehyde aqueous solution with a mass fraction of 25% and add it to 1000ml deionized water, then put hydroxyapatite / chitosan composite gel rods (10 pi...

Embodiment 3

[0033] 1) Weigh Ca(NO 3 ) 2 4H 2 O 2.35g and Na 2 HPO 4 1.44g was added to 400ml of dilute acetic acid aqueous solution with a volume fraction of 2%, and stirred for 10 minutes to form a hydroxyapatite precursor solution;

[0034] 2) Add 20 g of chitosan powder to the hydroxyapatite precursor solution, stir for 1 h, and leave the obtained mixed solution to defoam for 24 h;

[0035] 3) Take a small amount of chitosan solution and inject it into the mold to form a layer of inner film, then inject the mixed solution in step 2) into the mold, and then put the mold filled with the mixed solution into a 5% NaOH coagulation solution by mass fraction , solidified for 24 hours, and demolded to obtain a hydroxyapatite / chitosan composite gel rod, which was washed with distilled water until neutral;

[0036] 4) Measure 2.5ml of glutaraldehyde aqueous solution with a mass fraction of 25% and add it to 1000ml deionized water, then put hydroxyapatite / chitosan composite gel rods (10 piec...

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Abstract

The invention discloses a method for preparing a high-strength hydroxylapatite and chitosan three-dimensional composite rod material, which comprises the following steps: adding a calcium salt and a phosphate into solution of acetic acid to form solution of a hydroxylapatite precursor; dissolving chitosan powder in the solution of the precursor and standing the solution for deaeration; filling the mixed solution in a mold and obtaining a hydroxylapatite and chitosan three-dimensional composite gel rod material through the pervasion of alkaline coagulating liquid and self-assembly; and placing the hydroxylapatite and chitosan three-dimensional composite gel rod material in aqueous solution of glutaraldehyde and standing the solution for crosslinking, soaking and washing the resulting product with deionized water and drying the resulting product. The bending strength and bending modulus of the hydroxylapatite and chitosan three-dimensional composite gel rod material can reach 178MPa and 5.2GPa respectively, so the hydroxylapatite and chitosan three-dimensional composite gel rod material can meet clinic use requirements for fracture internal fixation.

Description

technical field [0001] The invention relates to a method for preparing a hydroxyapatite / chitosan three-dimensional composite rod. Background technique [0002] Because of population aging, pathological changes, traffic accidents, earthquakes and other reasons, a large number of fracture patients need fracture internal fixation every year. Many biomaterials prepared from metal and polymer materials are used for the treatment of orthopedic diseases, but these materials have significant defects, such as: the mechanical compatibility of metal materials with bone tissue is not good, resulting in loosening or Dislocation; produce stress shielding effect, resulting in fracture loosening or bone atrophy, can not form callus at the fracture site, prone to secondary fractures; the release of metal ions will cause allergic reactions; metal materials require secondary surgery to remove the implant; current clinical The polymer materials used release acidic substances when they degrade,...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14A61L31/02A61L31/04
Inventor 胡巧玲王征科
Owner ZHEJIANG UNIV
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