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Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing physical performance

A composition and technology of fire ants, which can be applied to nervous system diseases, drug combinations, cardiovascular system diseases, etc., and can solve problems such as accelerated AD lesions

Active Publication Date: 2009-12-02
SYNAPSIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, data now suggest that acetylcholinesterase inhibitors accelerate AD lesions

Method used

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  • Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing physical performance
  • Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing physical performance
  • Compositions and methods relating to solenopsins and their uses in treating neurological disorders and enhancing physical performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] 1. Example 1: Animal studies

[0136] Fire ant venom (FAV) was extracted from invasive fire ants from Charleston, SC and shipped in Teflon beakers to prevent escape of these ants. The ants (n=100) were placed in a 30ml glass tube containing ethane (5ml). The glass tubes were then sealed and the contents were analyzed for the presence of FAV alkaloids after 24 h. The ants release their venom upon contact with the solvent.

[0137] Fire ant venom (FAV) extracts were injected into aged rats (20 months) at various doses (1, 10 and 100 ng / kg (daily intraperitoneal injection)). After 7 days, animals were subjected to behavioral analysis using the Morris water maze and open-field testing. The animals showed dose-dependent improvements in age-related deficits compared to vehicle-injected animals. In addition, no adverse effects occurred in the animals at the doses given.

Embodiment 2

[0138] 2. Example 2: clinical research

[0139] Mr. D, 86 years old, widowed, American-born Caucasian male. Clinical observations included: weight loss of 25 pounds (lb.), lethargy, restlessness, depression, disorientation, and anxiety. Patients show marked reductions in cognitive function, particularly in the following areas: localization (time, place, person), recent memory, new learning ability, digit span, information and vocabulary, Numeracy and abstract thinking characteristic of mild to moderate Alzheimer's disease.

[0140] Patients who were incidentally exposed to FAV (20-30 bites, 20-30 units / 1 μl) within a 48-72 hour time window showed significant improvements in their baseline cognition, especially in the aforementioned aspects; During the follow-up of this patient (without a maintenance dose), although the patient had shown some cognitive decline, his cognitive ability remained significantly improved. Additionally, all signs of depression were absent; he gained...

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Abstract

Provided herein are piperidine alkaloids and uses thereof in neurological disorders and physical enhancement applications.

Description

[0001] Cross References to Related Applications [0002] This application claims priority based on US Provisional Application No. 60 / 806,887, filed July 10, 2006, the entire contents of which are incorporated herein by reference. Background technique [0003] A large number of diseases and disorders are known to be associated with the central nervous system, such as stroke and related ischemic diseases, spinal cord injury, peripheral nerve injury, traumatic brain injury, retinal degeneration, epilepsy (such as generalized, partial, or intractable epilepsy), neuropsychiatric disorders, pain disorders, and neurodegenerative disorders. Alzheimer's disease (AD) is often associated with the deposition of amyloid-beta (Aβ) peptides in the brain. Oxidative stress and inflammation are important pathogenic mechanisms in Alzheimer's disease (AD) and related disorders. Aβ peptides present in the brain play an important role in the formation of aggregates that can lead to neuronal damag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445
CPCA61K31/445A61P25/00A61P25/08A61P25/14A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28A61P27/02A61P9/00
Inventor D·多西M·S·金笛
Owner SYNAPSIN PHARMA
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