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Andrographolidume composition and application thereof

A kind of technology of andrographolide and composition, applied in the field of andrographolide composition

Active Publication Date: 2011-09-07
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the combination of andrographolide and lipoic acid has not been reported in the literature at home and abroad.

Method used

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  • Andrographolidume composition and application thereof
  • Andrographolidume composition and application thereof
  • Andrographolidume composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Add andrographolide (350g, 1mol) into R-alpha-lipoic acid (2063g, 10mol), fully mix, add medicinal starch 800.0g, etc., and press into 5000 tablets to obtain the andrographolide composition tablet agent.

Embodiment 2

[0071] Andrographolide (350g, 1mol) is joined in the (412g, 2mol) of S-alpha-lipoic acid, fully mix, add the mixture of 200g distilled water and 400g sucrose powder and dextrin (sucrose: dextrin=3: 1 ), mixed into a soft material, extruded and sieved (12 mesh to 14 mesh) to make granules, dried at 60°C, granulated, divided into plastic bags equivalent to 4.0g of andrographolide composition per bag, sealed, that is Obtain andrographolide composition granule.

Embodiment 3

[0073] Add 14-deoxyandrographolide (350g, 1mol) to R-α-dihydrolipoic acid (206g, 1mol), mix well, pass through 80 mesh sieve, mix with 150g starch, add 10% starch Slurry 100mL, stir to make soft material, press through 80-100 mesh sieve to granulate, dry at 60°C-70°C, granulate, add 0.2g of magnesium stearate, mix evenly, pack 1000 capsules, and obtain Andrographis paniculata. Ester composition capsules. Take orally, 1-3 capsules at a time, 3 times a day.

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Abstract

The invention discloses an andrographolidume composition and application thereof. The composition consists of a component I and a component II according to a molar ratio of between 1:10 and 10:1, wherein the component I is at least one of andrographolidume, andrographolidume derivatives and pharmaceutically acceptable salts of the andrographolidume derivatives, and the component II is at least one of lipoic acid and dihydrolipoic acid. The composition can be prepared into anticancer, anti-inflammatory, antibacterial, antivirus or hypoglycemic medicaments.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular to an andrographolide composition and its application. Background technique [0002] Andrographolide (Andrographolide) is the main active ingredient in the traditional Chinese medicine Andrographis paniculata. Andrographis paniculata is widely used in Asian countries, including China, India, Japan, Korea, etc., to treat inflammatory diseases, including rheumatoid arthritis, laryngitis, diarrhea, bacterial and viral infections. Studies have shown that andrographolide has broad-spectrum anti-cancer effects, and the treatment effect is good. In the past 30 years, andrographolide and its three derivatives, Chuanhuning, Yanhuning and Lianbizhi, have been widely used clinically in China. These drugs can alleviate clinical symptoms of inflammation, fever, bacterial and viral infectious diseases. These drugs are often referred to as "green antibiotics" because they are derived ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/385A61K31/365A61P35/00A61P29/00A61P31/00A61P31/12A61P3/10
Inventor 王玉强于沛蒋杰徐立朋张高小
Owner JINAN UNIVERSITY
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