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Medicinal composition fat emulsion injection containing eucalyptol, limonene and alpha-pinene and preparation method

A technology of limonene and eucalyptol, applied in the direction of drug combination, medical preparations containing active ingredients, medical preparations without active ingredients, etc., can solve the problems of inconvenient swallowing and unsatisfaction, and achieve the purpose of reducing bronchial mucosal swelling, Rapid onset of effects with clear active ingredients

Active Publication Date: 2009-12-02
BEIJING GRAND JOHAUM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product has won the approval of doctors and patients with its superior safety and definite curative effect, and achieved significant economic benefits after it was launched, but it cannot meet the needs of patients who are inconvenient to swallow and critically ill patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Under the protection of nitrogen, weigh 120g of soybean oil for injection, heat it to 60°C, add 13g of egg yolk lecithin for injection, 128mg of eucalyptol, 84mg of limonene, and 28mg of a-pinene, and stir until uniform at high speed to make an oil phase . In addition, add 23g of glycerin for injection into a container containing an appropriate amount of water for injection, mix well, heat to 65°C and filter, then mix with the oil phase under high-speed stirring to make colostrum, then add water for injection to 1000ml to make the colostrum through two steps Repeated emulsification by the high-pressure homogenizer until the milk particles pass the inspection (more than 97% of the particles are less than 1μ), and then filtered through a microporous membrane, filled in a 250-500ml glass bottle, passed through nitrogen, added a membrane, and sealed with a rubber stopper , rolled aluminum cover. Sterilize at 115°C for 30 minutes, and pack after passing the inspection.

Embodiment 2

[0037] Under the protection of nitrogen, weigh 150g of soybean oil for injection, heat it to 70°C, add 14g of egg yolk lecithin for injection, 256mg of eucalyptol, 168mg of limonene, and 56mg of a-pinene, and stir at high speed until uniform to form an oil phase . In addition, add 24g of glycerin for injection into a container containing an appropriate amount of water for injection, mix well, heat to 70°C and filter, then mix with the oil phase under high-speed stirring to make colostrum, and then add water for injection to 1000ml to make the colostrum through two steps Repeated emulsification by the high-pressure homogenizer until the milk particles pass the inspection (more than 97% of the particles are less than 1μ), and then filtered through a microporous membrane, filled in a 250-500ml glass bottle, passed through nitrogen, added a membrane, and sealed with a rubber stopper , rolled aluminum cover. Sterilize at 115°C for 30 minutes, and pack after passing the inspection....

Embodiment 3

[0039] Under the protection of nitrogen, weigh 200g of soybean oil for injection, heat to 55°C, add 8g of soybean lecithin for injection, 320mg of eucalyptol, 210mg of limonene, and 70mg of a-pinene and stir at high speed until uniform to form an oil phase. In addition, add 22g of glycerin for injection into a container containing an appropriate amount of water for injection, mix well, heat to 60°C and filter, then mix with the oil phase under high-speed stirring to make colostrum, and then add water for injection to 1000ml to make the colostrum through two steps Repeated emulsification by the high-pressure homogenizer until the milk particles pass the inspection (more than 97% of the particles are less than 1μ), and then filtered through a microporous membrane, filled in a 250-500ml glass bottle, passed through nitrogen, added a membrane, and sealed with a rubber stopper , rolled aluminum cover. Sterilize at 115°C for 30 minutes, and pack after passing the inspection.

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PUM

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Abstract

The invention aims to develop medicinal composition fat emulsion injection containing eucalyptol, limonene and alpha-pinene and a preparation method. The preparation comprises the following components in percentage by weight: 0.0128 to 0.0320 percent of eucalyptol, 0.0084 to 0.0210 percent of limonene, 0.0028 to 0.0070 percent of alpha-pinene, 10 to 30 percent of soybean oil for injection, 1.0 to 1.5 percent of yolk lecithin for injection or 0.8 to 1.5 percent of soybean phospholipids for injection, 2.0 to 2.5 percent of glycerol for injection, and water for injection added to 100 milliliters. The preparation method has the characteristics of strong controllability of production quality, and definite treatment effect of a product. The invention fills up the blank of the medicinal composition fat emulsion injection preparation containing the eucalyptol, the limonene and the alpha-pinene.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations. Specifically relates to a fat emulsion injection containing eucalyptol, limonene and α-pinene pharmaceutical composition and a preparation method. Background technique [0002] Phlegm is the product of respiratory inflammation, which can irritate the respiratory mucosa, cause cough and asthma, and aggravate infection. When patients with acute and chronic bronchitis or chronic lung disease have respiratory failure, if the patient's sputum is too viscous or forms sputum plugs, it can block the airway and cause suffocation. Therefore, it is of great significance to use mucus sputum regulators to dissolve mucus sputum, make it thinner, lower its viscosity, accelerate the movement of mucous membranes and cilia in the respiratory tract, and improve the transport function. [0003] The currently marketed mucus regulators, such as bromhexine, sodium thioethanesulfonate, and carbocys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61K31/015A61K9/107A61K47/44A61K47/24A61P11/10A61P3/02A61P11/00A61P11/14A61P11/02A61P11/08A61P11/12
Inventor 黄志武张宁
Owner BEIJING GRAND JOHAUM PHARMA CO LTD
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