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Special micro-fluidic chip for cholera diagnosis with one-dimensional self-assembly magnetic bead chain electrodes

A microfluidic chip and self-assembly technology, applied in the field of testing, to achieve the effect of reducing dosage, speeding up efficiency and reducing the cost of cholera diagnosis

Inactive Publication Date: 2009-11-25
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] At present, in the field of microfluidic chip technology, the technology of using multiple characteristic antibodies of cholera to simultaneously detect and rapidly diagnose cholera has not been reported.

Method used

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  • Special micro-fluidic chip for cholera diagnosis with one-dimensional self-assembly magnetic bead chain electrodes

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Embodiment Construction

[0026] exist figure 1 In the shown example of this case, the structure of the microfluidic chip includes two plates that are attached together, and the two plates are respectively the cover sheet of the microfluidic chip and the base of the microfluidic chip. sheet, a capillary channel is installed at the position where the two plates fit together, and three micro-reservoirs, the three micro-reservoirs are micro-reservoir 1, micro-reservoir 2 and a micro-reservoir 10, one end of the capillary channel communicates with the micro-reservoir 1 and the micro-reservoir 2 via the Y-shaped triple channel 3, and the other end of the capillary channel communicates with the remaining micro-reservoir 10, and , the working electrode, the counter electrode 8 and the reference electrode 9 respectively installed at different positions in the capillary channel in sequence, the beaded working electrode is composed of a conductive electrode and an antibody substance surface layer coated on the c...

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Abstract

The invention relates to a special micro-fluidic chip for cholera diagnosis with one-dimensional self-assembly magnetic bead chain electrodes, belonging to the field of testing. Rapid diagnosis of fulminating infectious disease cholera with low cost is one of many expectations in the development of medical technology, and the invention provides a micro-fluidic chip for simultaneously detecting and rapidly diagnosing cholera by using multiple characteristic antibodies of cholera. The chip is provided with three micro liquid storage tanks, and the invention is characterized in that capillary passages in parallel configuration contain in the chip, the parallel configuration contains four micro-passages that are mutually in parallel, four magnetic bead chain working electrodes are respectively installed inside the four micro-passages, the surface substances of the four magnetic bead chain working electrodes are respectively four antibody substances that are cholera TP0821 antibody, cholera TP0319 antibody, cholera TP0624 antibody and cholera O139 mycoprotein antibody. The integrated structure and the appearances of specific magnetic bead chain working electrodes facilitate to improve the diagnosis efficiency of cholera diseases.

Description

technical field [0001] The invention relates to a special microfluidic chip for diagnosing cholera with a one-dimensional self-assembled magnetic bead chain electrode, which belongs to the field of testing. Background technique [0002] Cholera is a severe infectious disease caused by Vibrio cholerae, which belongs to the international quarantine infectious disease and is also one of the pathogens of Class A infectious diseases stipulated in the Law of the People's Republic of my country on the Prevention and Control of Infectious Diseases. The disease is characterized by acute onset, rapid spread, and wide coverage, which can cause local and worldwide outbreaks; it is an infectious disease that seriously endangers human health and life. Vibrio cholerae is a pathogenic bacterium that causes severe diarrhea in infected persons. As an international quarantine infectious disease-cholera, the pathogenic diagnosis of cholera is based on the detection of Vibrio cholerae O1 or O139...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569G01N33/543G01N27/327G01N27/48
CPCY02A50/30
Inventor 干宁李榕生杨欣王峰王鲁雁巫远招李天华
Owner NINGBO UNIV
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