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Compound microporous starch powder hemostat and preparation method thereof

A technology of microporous starch and hemostatic agent, which is applied in medical science, absorbent pads, surgery, etc., can solve problems affecting water absorption performance and pore structure damage, and achieve the effects of increased water absorption speed, improved hemostatic performance, and excellent water absorption rate

Inactive Publication Date: 2009-10-21
官培龙 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, in the current process of preparing microporous starch, wet microporous starch and warm cross-linked microporous starch all adopt the vacuum drying method; and the microporous starch granules prepared by this method will have a certain degree of damage to the pore structure; Especially during the grinding process after drying, which affects their water absorption properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of potato and sweet potato cross-linked microporous starch:

[0031] Potato is an annual herb of Solanaceae Solanaceae, also known as potato. Potato tubers contain 76.3% moisture and 23.7% dry matter, including 17.5% starch, 0.5% sugar, 1% to 2% protein and 1% inorganic salt. Potato starch granules are larger, oval or round in shape, with a particle diameter of 25-100um; it is characterized by sufficient viscosity and stable paste, but slightly poor water absorption. Microporous starch is a honeycomb porous starch granule formed on the surface of the natural raw flour after enzymatic hydrolysis. The surface pore diameter is about 1um, and the volume of the pores accounts for about 60% of the particle volume. It has good adsorption.

[0032]The main component of sweet potato is starch, which accounts for about 18%-25% of the weight of fresh potato. The sweet potato starch granules are oval or polygonal in shape and loose in structure. Sweet potato starch ...

Embodiment 2

[0040] Determination and comparison of hemostatic efficacy:

[0041] The particle size of the hemostatic powder was measured by AccuSizer780 / SIS (PSS, USA) company particle size measurement system, and the microporous particles of potato starch were 15-100 μm; the microporous particles of sweet potato starch were 5-31 μm. Scanning electron microscopy shows that the potato starch microporous particles are oval, with small pores and cracks on the surface; sweet potato starch microporous particles have many small pores on the surface, and there are multiple pore structures inside, with a pore size of about 1 μm, and the pore size is basically the same . The wound exudate was used to simulate the body fluid environment, and the swelling rate of the particles reached 320% in 20 seconds; in the rabbit liver hemorrhage model, the hemostatic effect was equivalent to that of the American Arista hemostatic powder.

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Abstract

The invention belongs to the technical field of medical preparations, and in particular discloses a compound microporous starch powder hemostat and a preparation method thereof. The compound microporous starch powder hemostat uses potato starch and sweet potato starch as raw materials. The preparation method comprises the following steps: performing pregelatinization and ultrasonic pretreatment on the potato starch and the sweet potato starch, and then performing enzymatic hydrolysis on the potato starch and the sweet potato starch respectively to make pores so as to prepare microporous starches of the potato starch and the sweet potato starch respectively; in the process of enzymatic hydrolysis to prepare the microporous starches, adopting a vacuum freeze-drying method for drying the starches; using sodium trimetaphosphate to crosslink starch molecules so as to strengthen the structure; and mixing the potato crosslinking microporous starch and the sweet potato crosslinking microporous starch according to certain proportion to obtain the compound microporous starch powder hemostat. The microporous starch prepared by the method has strong hydroscopic property and obviously improved water-absorbing speed; besides, compared with the prior single-starch polysaccharide hemostatic material, the ingredients of the compound have improved performance and good hemostatic effect.

Description

technical field [0001] The invention belongs to the technical field of medical preparations, and in particular relates to a microporous starch powder hemostatic agent and a preparation method thereof. Background technique [0002] Bleeding is one of the common problems in the perioperative period. Local hemostatic drugs and materials can control wound bleeding and ensure a clear surgical field, which is of positive significance for reducing trauma, improving surgical efficiency, and accelerating postoperative recovery of patients. Local hemostatic materials are of great significance especially for the treatment of solid organ (brain, kidney, liver, etc.) wound bleeding (high brittleness, rich blood flow, easy tissue damage caused by suturing, needle hole bleeding and difficult to be effective); at the same time, Because it can reduce the amount of bleeding in patients and reduce the amount of blood transfusion during surgery, thereby greatly reducing the economic burden on ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/60A61L31/04C08B30/02C08B30/06C08B31/00
Inventor 官培龙饶蓉
Owner 官培龙
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