Steroidal compound in Bugula neritina L. and use thereof

Abstract

The invention relates to the field of medical technology and discloses a new steroidal compound which is extracted in marine animal Bugula neritina L. and the application thereof in the preparation of anti-tumor drugs. The general formula of the chemical structure thereof is as follows: the in vitro activity test proves that the steroidal compound has significant anti-tumor activity to three different tumor cells of HepG2, HT-29 and NCI-H460, and the IC50 value is close to or even better than a positive control drug which is vincristine, thereby being capable of being used for preparing the anti-tumor drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a novel steroid compound extracted from the marine animal Borglaneritina genus Bugulaneritina and its application in the preparation of antitumor drugs. Background technique [0002] B. neritina is a true coelom, which is widely distributed in the waters of the world. It is found in the saline waters of my country's coastal areas from the Bohai Sea to the Xisha Islands in the South China Sea. The group is reddish-brown or purple-brown, in the shape of tufts, 40-150mm high, and each branch has two rows of worms, arranged alternately. Its groups often attach to kelp, agarose, shellfish, and underwater facilities such as ship bottoms, docks, and navigation marks, affecting marine aquaculture, national defense, and marine traffic, and is one of the main marine fouling organisms. The applicant once isolated a macrolide compound with anti-tumor activity from this bryozoa and applied fo...

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Problems solved by technology

But so far there is no report of extracting steroidal compounds with anti-tumor activity from it.

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