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Suspension composition containing doxycycline and florfenicol for injection and technique for preparing the same

A technology of florfenicol and doxycycline, applied in the field of medicine, can solve the problems of animal body stimulation and the like, and achieve the effects of reduced dosage, low cost and simple preparation

Inactive Publication Date: 2009-08-12
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, there is a great risk in the use of the preparation, and it will also cause great irritation to the animal body.

Method used

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  • Suspension composition containing doxycycline and florfenicol for injection and technique for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] components

[0035] Doxycycline 20g

[0036] Florfenicol 20g

[0037] Anhydrous sodium sulfite 0.2g

[0038] Disodium edetate 0.04g

[0039] Polyvinylpyrrolidone k30 0.40g

[0040] Sodium carboxymethylcellulose 0.3g

[0041] Tween-80: 0.3g

[0042] Sodium citrate: 5.0g

[0043] Methylparaben 0.03g

[0044] Add water for injection to 100ml

[0045] The preparation process is:

[0046] (1) Dissolve disodium edetate, sodium citrate and anhydrous sodium sulfite in sequence in 20 ml of water for injection, and filter with a 0.45 μm microporous membrane to obtain solution A.

[0047] (2) Take 10ml of water for injection, add methyl paraben, heat to dissolve and cool to room temperature, then add 50ml of water for injection, dissolve in sodium carboxymethylcellulose, add polyvinylpyrrolidone k30 and Tween -80, after stirring evenly, filter with a 0.45 μm microporous membrane to obtain solution B.

[0048] (3) Pour solution B into solution A, stir and mix evenly, add...

Embodiment 2

[0052] components

[0053] Doxycycline 30g

[0054] Florfenicol 30g

[0055] Anhydrous sodium sulfite 0.2g

[0056] Sodium formaldehyde sulfoxylate 0.2g

[0057] Disodium edetate 0.04g

[0058] Polyvinylpyrrolidone k30 0.40g

[0059] Sodium carboxymethylcellulose 0.4g

[0060] Lecithin: 0.5g

[0061] Sodium citrate: 4.2g

[0062] Potassium dihydrogen phosphate 2.4g

[0063] Methylparaben 0.02g

[0064] Ethylparaben 0.02g

[0065] Add water for injection to 100ml

[0066] The preparation process is:

[0067] (1) Dissolve disodium edetate, sodium citrate, potassium dihydrogen phosphate, sodium formaldehyde sulfoxylate and anhydrous sodium sulfite in sequence in 20ml of water for injection, and filter with a 0.45 μm microporous membrane to obtain Solution A.

[0068] (2) Take 10ml of water for injection, add methylparaben and ethylparaben, heat to dissolve and cool to room temperature, then add 50ml of water for injection, dissolve sodium carboxymethylcellulose and add...

Embodiment 3

[0073] components

[0074] Doxycycline 10g

[0075] Florfenicol 10g

[0076] Sodium formaldehyde sulfoxylate 0.2g

[0077] Disodium edetate 0.04g

[0078] Polyvinylpyrrolidone k30 0.35g

[0079] Sodium carboxymethylcellulose 0.25g

[0080] Tween 80: 0.3g

[0081] Sodium citrate: 4.2g

[0082] Potassium dihydrogen phosphate 2.0g

[0083] Methylparaben 0.02g

[0084] Ethylparaben 0.02g

[0085] Add water for injection to 100ml

[0086] The preparation process is:

[0087] (1) Dissolve ethylenediaminetetraacetic acid disodium, sodium citrate, potassium dihydrogen phosphate and sodium formaldehyde sulfoxylate in 20ml of water for injection in sequence, and filter with a 0.45 μm microporous membrane to obtain solution A.

[0088] (2) Take 10ml of water for injection, add methylparaben and ethylparaben, heat to dissolve and cool to room temperature, then add 50ml of water for injection, dissolve sodium carboxymethylcellulose and add poly Vinylpyrrolidone k30 and Tween-80...

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Abstract

The invention relates to a high-concentration injectable suspension combination containing doxycycline and florfenicol and a preparation process thereof. The suspension combination comprises the following components: 4.0 % to 30.0% (W / V) of florfenicol, 4.0 % to 30.0% (W / V) of doxycycline, 0.05% to 0.40% (W / V) of anti-oxidant, 0.01% to 0.04 % (W / V) of complexing agent, 0.01% to 15% (W / V) of suspending agent, 1.0% to 10.0% (W / V) of flocculating agent, 0.01% to 0.5% (W / V) of antiseptic agent and 60% to 100% of water for injection. The invention has the advantages that the component content of the drug is high, the administration volume is small, animal suffers less pain and irritation, adverse reactions, safety accidents and the like caused by the organic solvent are reduced, the preparation cost is low and the preparation is simple. The invention is applicable in preventing and treating the mixed bacterial infection diseases of domestic animals and the like.

Description

technical field [0001] The invention relates to an injectable suspension combination containing doxycycline and florfenicol and a preparation process thereof, which is used for preventing and treating bacterial diseases of livestock and poultry, and belongs to the technical field of medicines. Background technique [0002] Bacterial diseases of livestock and poultry are common and frequently-occurring diseases in the current large-scale farms and farmers' breeding process, and have become the main factor that endangers the livestock and poultry breeding industry. Due to the limitations of the application of bacterial vaccines, drug therapy has become an important measure to control bacterial diseases. In the process of treatment, due to the abuse and irrational use of drugs, the drug resistance of bacteria, especially the multi-drug resistance, is becoming more and more serious. health, causing huge economic losses and social harm. Therefore, the development of safe, effic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/65A61K31/165A61P31/04
Inventor 马丽伟富艳玲刘爱玲李旭东
Owner TIANJIN RINGPU BIO TECH
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