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Partition method for crossing-overlapped chromosome

A chromosome and intersection technology, applied in the segmentation of overlapping and overlapping chromosomes, can solve the problems of segmentation errors, misjudgment of concave points, and consumption, and achieve the effect of high accuracy and efficiency improvement.

Inactive Publication Date: 2009-08-05
GUANGDONG VTRON TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some of these chromosome automatic analysis systems have good results, they have not reached a satisfactory level, especially in the segmentation of chromosome overlap and cohesion images, chromosome feature extraction and band analysis.
[0003] In the existing automatic chromosome analysis system, manual segmentation is mostly used for cross-overlapping chromosomes, that is, manually select four cutting points of cross-overlapping chromosomes for segmentation. This manual method requires a lot of time and manpower.
In addition to other automatic segmentation methods, the concave point is selected as the cutting point of chromosome segmentation through the chromosome edge features, but the requirements for the contour of the chromosome part outside the cross-overlapping region of the cross-overlapping chromosome are higher, for example, there cannot be A large degree of bending, otherwise it is easy to misjudge the concave point, resulting in segmentation errors

Method used

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  • Partition method for crossing-overlapped chromosome
  • Partition method for crossing-overlapped chromosome
  • Partition method for crossing-overlapped chromosome

Examples

Experimental program
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Embodiment 1

[0042] The technical solution in this embodiment is to segment cross-overlapping chromosomes based on the measurement of the length of normal line segments. Among them, specifically include the following steps:

[0043] Step 1, the overlapping area of ​​the first chromosome and the second chromosome is the central area; draw a line segment along the skeleton direction of the first chromosome in the central area according to the received line drawing instruction, and the length of the line segment is greater than the width of the second chromosome. Before performing this step, it is generally necessary to perform some preprocessing and edge detection on the images of crossed and overlapping chromosomes. This step is the same as the preprocessing and edge detection steps of chromosome analysis in the prior art. Firstly, the chromosome image is preprocessed by removing miscellaneous information, noise and increasing image contrast; then, edge detection is performed on the chromos...

Embodiment 2

[0063] The technical solution in this embodiment is to segment cross-overlapping chromosomes based on the length measurement of parallel line segments. Among them, specifically include the following steps:

[0064] Step 1, the overlapping area of ​​the first chromosome and the second chromosome is the central area; draw a line segment in the central area along the skeleton direction of the first chromosome after receiving a line drawing instruction, and the length of the line segment is greater than the width of the second chromosome. Similarly, before performing this step, it is necessary to perform preprocessing on the chromosome image to remove miscellaneous information, noise points and increase image contrast; then use the differential operator to perform edge detection on the chromosome image.

[0065] Step 2, calculate the slope of the line segment and its normal slope, and obtain the calculation result.

[0066] The above two steps are the same as the corresponding st...

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Abstract

The invention provides a method for partition cross overlapping chromosome which relates to the medicine microimage image analysis field of digital medical treatment. The method includes steps as follows: firstly, describing line segment in a central region of the cross overlapping chromosome; secondly, calculating slope ratio of the line segment and normal slope ratio of the line segment and obtaining the calculated result; thirdly, measuring the line segment length according with the calculated result and confirming a partition point according with the measured result; fourthly, partition the cross overlap chromosome according with the partition point. The method provided by the invention judges the partition point based on the method for measuring the line segment length and processes chromosome partition according to this which can reduce difficulty and working amount of manpower partition, increase automatization degree for analyzing chromosome, and has simple arithmetic.

Description

technical field [0001] The invention relates to the field of medical microscopic image analysis of digital medical treatment, and specifically proposes a method for segmenting cross-overlapped chromosomes. Background technique [0002] With the continuous integration and development of multimedia communication technology and video information application in the field of modern medicine, the diagnosis and treatment of hospitals are increasingly dependent on modern multimedia digital medical examination results. Imaging tests such as microscopes, X-rays, CT, MRI, ultrasound, gastroscopy, and speculum are also becoming more common. Digital medical care is to provide the collection, storage, processing, extraction and data exchange of patient information and management information for various departments of the hospital through computer science, modern network communication technology and database technology, and to meet the functional requirements of all authorized users. Espe...

Claims

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Application Information

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IPC IPC(8): G06T5/00
Inventor 林道庆刘国平
Owner GUANGDONG VTRON TECH CO LTD
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