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Pharmaceutical composition for treating female barrenness

A composition and infertility technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor curative effect, large side effects and sequelae, and aggravating the suffering of patients.

Active Publication Date: 2011-07-27
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current medical and surgical treatment is not only expensive but also aggravates the pain of patients, the cure rate is not high, the recurrence is large, and the side effects and sequelae are large.
In view of the fact that most of the current western medicines act on a single target or link, resulting in poor curative effect

Method used

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  • Pharmaceutical composition for treating female barrenness
  • Pharmaceutical composition for treating female barrenness
  • Pharmaceutical composition for treating female barrenness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0286] The preparation of pharmaceutical composition oral liquid:

[0287] Raw materials: Epimedium 300g, Polygonatum 240g, Dipsacus 240g, Rhizoma Cyperi 180g, Shichangpu 180g, Licorice 120g.

[0288] Preparation: add 12 times the amount of water to Cyperus cyperi and Shichangpu, distill for 6 hours to extract the volatile oil, and collect the distilled aqueous solution in another device; add 12 times the amount of water to the dregs and decoct for 1 hour, filter the liquid medicine for later use; the remaining 4 flavors are separated Decoct with 10 times the amount of water for 3 times, 2 hours each time, combine the decoction, filter, combine the filtrate with the above medicinal solution, concentrate under reduced pressure to a relative density of 1.10-1.12 (60°C), let stand for 24 hours, take the above The supernatant was recovered from ethanol and concentrated to a relative density of 1.04 (20°C), left to stand for 48 hours, and the supernatant was filtered, and the filtr...

Embodiment 2

[0291] The preparation of pharmaceutical composition mixture:

[0292] Raw materials: Epimedium 300g, Polygonatum 240g, Dipsacus 240g, Rhizoma Cyperi 180g, Shichangpu 180g, Licorice 120g.

[0293] Preparation: Add 8 times the amount of water and 4 times the amount of water to decoct the above six flavors respectively. After each decoction, keep warm at 85°C for 20 minutes, filter, combine the filtrates, and concentrate under reduced pressure until the relative density is not less than 1.06 ( 80° C.), centrifuge, take the supernatant, add 200 g of sucrose, 3 g of sodium benzoate, and 0.5 g of ethylparaben, add water to make 1000 mL, mix well, and fill to obtain the mixture.

[0294] Dosage: twice a day, 50ml each time.

Embodiment 3

[0296] The preparation of pharmaceutical composition syrup:

[0297] Raw materials: Epimedium 300g, Polygonatum 240g, Dipsacus 240g, Rhizoma Cyperi 180g, Shichangpu 180g, Licorice 120g.

[0298] Preparation: Add 12 times the amount of water to Cyperus cyperi and Shichangpu, distill for 6 hours to extract the volatile oil, and collect the distilled aqueous solution in another device; wrap the volatile oil with 6 times the amount of β-cyclodextrin to synthesize an inclusion compound. Add 12 times the amount of water to the dregs and decoct for 1 hour, and filter the liquid for later use; decoct the remaining 4 flavors with 10 times the amount of water for 3 times, each time for 2 hours, combine the decoction, filter, and the filtrate and the above medicine The liquids were combined, concentrated under reduced pressure to a relative density of 1.10-1.12 (60°C), and left to stand for 24 hours. The supernatant was taken to recover ethanol and concentrated to a density of 1.18. Anot...

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Abstract

The invention discloses a pharmaceutical composition for the treatment of female infertility as well as a preparation method and a quality control method thereof, the composition is any one of pharmaceutically acceptable preparations such as pellet, granule, tablet, syrup, mixture, oral liquid, dripping pill, capsule and injection prepared by epimedium brevicornum, sealwort, teasel root, astragalus root, rhizome cyperi and licorice. The quality control method thereof comprises the steps of: thin-layer identification of the epimedium brevicornum, sealwort, radix dipsaci, licorice, licorice andastragalus root; HPLC content measurement of the epimedium brevicornum, radix dipsaci and licorice; measurement of total contents of flavone and saponin. The pharmacodynamical experiments include: invivo experiment, in vitro cell experiment and clinical experiment. The experiments demonstrate that: the inventive pharmaceutical composition has the effects of warming kidney, replenishing sperm andconditioning emmenia, and the pharmaceutical composition can be used for the treatment of the female infertility.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation method and quality control method, in particular to a pharmaceutical composition for treating female infertility and its preparation method and quality control method. Background technique [0002] It is generally believed that couples of childbearing age live together after marriage, do not use contraception, have normal sex life, and the phenomenon that the woman has not conceived for more than two years (the American Obstetrics and Gynecology Textbook and Infertility Association sets the time as one year) is called "infertility". . Infertility or infertility caused by the man is called "male infertility" or "male infertility", and common people generally refer to it as infertility. There are many pathogenic factors for female infertility, and the pathogenesis is quite complicated. The main factor is egg maturation disorder and so on. The main factors of male infertility are ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/00A61K9/20A61P15/08
Inventor 徐玲玲乐秀珍年华张玉萱
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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