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Spikenard volatile oil and use of composition containing spikenard volatile oil in pharmacy

A technology of pine pine volatile oil and composition, which is applied to the treatment or prevention of arrhythmia in animals including humans, and the new application field of composition in pharmaceuticals, which can solve the problems such as the anti-arrhythmia effect of volatile oil that has not been reported

Inactive Publication Date: 2009-07-01
ZHEJIANG ZHENGFANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ma Chuangeng et al. (Ma Chuangeng, Xiang Siyuan et al. Experimental research on the antiarrhythmic effect of Gansong ethanol extract. Journal of Anhui Medical College, 1980, 15(4): 9) found that intravenous injection of ethanol extract has certain antiarrhythmic effect. Arrhythmic effects, but no antiarrhythmic effects of volatile oils have been reported so far

Method used

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  • Spikenard volatile oil and use of composition containing spikenard volatile oil in pharmacy
  • Spikenard volatile oil and use of composition containing spikenard volatile oil in pharmacy
  • Spikenard volatile oil and use of composition containing spikenard volatile oil in pharmacy

Examples

Experimental program
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Effect test

Embodiment 1

[0017] The preparation of embodiment 1 nard pine volatile oil

[0018] Take 1000 g of crushed Nardinus edulis, put it into a distillation device, pass through atmospheric pressure steam for distillation for 6 hours, condense the oily steam, separate the oil and water to obtain crude oil, add sodium sulfate to dry the crude oil, and filter to obtain 14.7 g of Nardinus volatile oil. The shape is light green transparent oily liquid with a sweet smell. Density 0.952g / ml.

Embodiment 2

[0019] Example 2 Effects of Nardinus volatile oil on sodium ion channels in cardiomyocytes

[0020] 1. Materials and methods

[0021] 1.1 Test solution of pine pine volatile oil: Dissolve 1.0 g of pine pine volatile oil obtained in Example 1 with dimethyl sulfoxide, add normal saline and dilute to 1000ml to obtain pine pine volatile oil test solution (1:1k), equivalent to crude drug 68g / L. Dilute the pine pine volatile oil test solution (1:1k) 20 times to obtain the pine pine volatile oil test solution (1:20k), which is equivalent to 3.4g / L crude drug.

[0022]1.2 Rat cardiomyocyte separation method: 8 rats, weighing 200-300 grams, male or female, intraperitoneally injected 1000 units (1ml) heparin, 15 minutes later intraperitoneally injected 25-50mg (1ml) sodium barbital for anesthesia, quickly opened The heart was taken from the chest, and perfused in a Langendorff perfusion device under the condition of constant temperature and oxygen supply at 37°C. First, it was perfus...

Embodiment 3

[0030] Example 3 Effect of nard pine volatile oil on the effective refractory period of rat ventricular myocardium and its correction value

[0031] 1. Materials and methods: A total of 50 healthy male Wistar rats (250±50 g) were divided into a treatment group (n=40) and a control group (n=10). Medication groups were all given the pine pine volatile oil test solution (1:20K) in Example 2 (equivalent to crude drug 3.4g / L). The medication group was divided into epicardial local infiltration (n=20) and airway inhalation administration group (n=20), and the control group was given pine pine volatile oil solvent. The administration method of local epicardial infiltration is to drop 0.2ml of the medicinal solution to the epicardium, and the administration method of airway inhalation is to drip the medicinal solution 0.2ml (equivalent to 10ug of volatile oil, or equivalent to 0.68mg of crude drug) to the cotton As for the side tube in the three-way tube, one end of the three-way tub...

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Abstract

The invention relates to a volatile oil of Nardostachys chinensis Batal and combination comprising the volatile oil and new use thereof in pharmacy, wherein the volatile oil treats or prevents arrhythmia of human and other animals. The volatile oil of Nardostachys chinensis Batal plays the role of inhibition on rat cardiac myocytes sodium ion channel with very wide therapeutic window and very high safety. Epicardial local infiltration and airway inhalation administration all can prolong the effective refractory period of rat cardiac muscle.

Description

Technical field [0001] The present invention relates to the new application of nardone volatile oil in pharmacy, also relates to the new application of the composition containing nard pine volatile oil in pharmacy, and this medicine is used for treating or preventing the arrhythmia of animal including human; Also relates to this medicine or Its composition is administered by pulmonary, nasal and oral administration. Background technique [0002] Arrhythmia is one of the main causes of death from various heart diseases, especially in heart failure, myocardial ischemia or myocardial infarction, the incidence and mortality of arrhythmia are higher. However, the total effective rate of antiarrhythmic drugs is only 30%-60% (Zhou Jiang, Zhao Fei. Observation on the clinical efficacy of Wenxin Granules in the treatment of arrhythmia. Chinese Medicine, 2006, 1(6): 342-343). So far, all the antiarrhythmic western medicines have proarrhythmic effects while being antiarrhythmic. 13%,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/12A61P9/06A61K31/12A61K31/015A61K31/045
Inventor 葛郁芝吴志婷吴炜玮
Owner ZHEJIANG ZHENGFANG PHARMA TECH
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