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Neutral desorption apparatus and neutral desorption extractive electrospray lonization mass spectrometry method

A neutral desorption and electrospray technology, applied in the field of analytical chemistry, can solve the problem of inability to analyze complex samples online, and achieve the effects of in-situ rapid analysis, high sensitivity and convenient use.

Active Publication Date: 2009-06-17
江西正谱奕和科技有限公司
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Problems solved by technology

However, in application, pure EESI also has shortcomings, that is, because there is no surface desorption device, it cannot be used to directly measure substances on solid surfaces, so it cannot perform direct real-time on-line analysis of complex samples on the surface of living bodies

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  • Neutral desorption apparatus and neutral desorption extractive electrospray lonization mass spectrometry method
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  • Neutral desorption apparatus and neutral desorption extractive electrospray lonization mass spectrometry method

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Embodiment Construction

[0034] The composition and working principle of the neutral desorption device of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0035] figure 1 , figure 2 The basic composition and working principle of the neutral desorption device system of the present invention are shown. In mass spectrometry, the neutral desorption device is used as a sample introduction system, which mainly includes an air inlet pipe I and a sample output pipe II, both of which are capillary tubes, and the two capillary tubes are placed obliquely and fixed on In the frame 1, the outlet of the inlet pipe I and the inlet of the sample output pipe II are close to and protrude out of the frame, the angle between the inlet pipe I and the sample output pipe II is 45-150°, and the positions and angles of the two capillaries are It can be adjusted by the spring 11 and the bolt 12 provided in the frame 1; the inlet of the inlet pipe I communicates with a...

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Abstract

The invention discloses a neutral desorption device and a neutral desorption extraction electrospray ionization mass spectrographic (ND-EESI-MS) analysis method. The neutral desorption device mainly comprises an air inlet tube and a sample tube which are diagonally arranged, and are fixed in a frame, an outlet of the air inlet tube is adjacent to an inlet of the sample tube and stretches out of the frame, wherein, an inlet of the air inlet tube is communicated with an air pump which conveys neutral gas to the air inlet tube, an outlet of the sample tube is communicated with a sample feed tubeof an EESI, the outer layer of the air inlet tube is equipped with a heating jacket, and can be further equipped with a liquid charging tube, and an outlet of the liquid charging tube is adjacent to the outlet of the air inlet tube and the inlet of the sample tube. The ND-EESI-MS analysis method is that the neutral desorption device collects samples and introduces sample flow into an extraction electrospray ionization source through the outlet of the sample tube for mass spectrographic analysis. The device and the method are especially applicable to rapid and real-time analysis of complex biological samples, food, medicines, environmental samples and the like, and also can perform in situ in vivo analysis on organisms.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to a sample introduction system used in conjunction with a mass spectrometer ion source in a mass spectrometry method, specifically a neutral desorption device that isolates a high-voltage electric field or charged particles from a detected object in time and space , and a technique for in situ non-destructive mass spectrometry analysis of samples using the neutral desorption device and electrospray extraction ionization source. Background technique [0002] The development of modern social economy and science and technology poses new challenges to analytical chemistry. The development of in-situ, real-time, on-line, non-destructive, high-throughput, high-sensitivity, high-selectivity, and low-loss analytical testing methods is the focus and goal of modern analytical science. Among many analytical testing methods, mass spectrometry is considered to be a universal method with hig...

Claims

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Application Information

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IPC IPC(8): G01N27/64H01J49/26
CPCH01J49/145H01J49/165H01J49/0463
Inventor 陈焕文张燮李建强丁健桦杨水平胡斌
Owner 江西正谱奕和科技有限公司
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