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Ureide derivative and use thereof for medical purposes

A technology of derivatives and ureides, applied in the field of ureide derivatives and their pharmaceutical applications

Inactive Publication Date: 2009-06-10
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] However, none of these patent documents describe the ureide derivatives of the present invention, and none of these documents suggest the efficacy of the compounds of the present invention as drugs

Method used

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  • Ureide derivative and use thereof for medical purposes
  • Ureide derivative and use thereof for medical purposes
  • Ureide derivative and use thereof for medical purposes

Examples

Experimental program
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Embodiment Construction

[0052] In general formula (I) and (IIa)-(IIf) of the present invention, by A 3 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , or R 15 The alkyl group with 1-6 carbon atoms represented is a linear, branched, or cyclic alkyl group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl , cyclopropyl, cyclopropylmethyl, n-butyl, sec-butyl, tert-butyl, hexyl, or cyclohexyl.

[0053] by R 6 , R 12 or R 15 Denoted aralkyl having 7 to 12 carbon atoms is, for example, benzyl, phenethyl, naphthylmethyl, or naphthylethyl.

[0054] by R 6 , R 7 , or R 14 The acyl group having 2-8 carbon atoms represented is an aliphatic or aromatic acyl group having 2-8 carbon atoms, such as acetyl, propionyl, butyryl, isobutyryl, pivaloyl, benzoyl, ortho Toluoyl, m-toluoyl, p-toluoyl, o-methoxybenzoyl, m-methoxybenzoyl, or p-methoxybenzoyl.

[0055] by A 3 , R 1 , R 2 , R 3 , R 4 , R 9 , or R 10 The halogen atom represen...

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Abstract

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

Description

technical field [0001] The present invention relates to ureide derivatives and their pharmaceutical applications. Background technique [0002] The term "pain" means an "unpleasant sensation" or an "experience involving unpleasant emotions" when tissue is or may be damaged, or expressed by terms indicative of such damage or "experiences involving unpleasant emotions". [0003] Pain occurs when tissue is damaged by disease or external injury, and pain-producing substances are produced locally. Nociceptive pain, especially when the body is stimulated externally (eg, by an external injury) or when internal tissue is damaged. [0004] An example of other types of pain that produce mechanisms other than nociceptive pain is neuropathic pain. Neuropathic pain is caused by dysfunction in the central nervous system or damage to peripheral nerves due to abnormalities in surrounding tissues or peripheral nerve endings. In addition, neuropathic pain occurs when the central nervous s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D263/48A61K31/4525A61K31/4535A61K31/454A61K31/46A61K31/496A61P25/04A61P29/00C07D277/20C07D277/42C07D401/04C07D405/04C07D409/04C07D413/04C07D417/04C07D451/02
CPCC07D263/48C07D277/20C07D413/04C07D409/04C07D417/04C07D451/02C07D405/04C07D277/42C07D401/04A61P25/04A61P29/00
Inventor 菅原雄二泉本直树筒井英之
Owner TORAY IND INC
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