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Treatment for depressive disorders

A technology for depression and mental disorders, applied in the direction of medical preparations containing active ingredients, metabolic diseases, drug combinations, etc., can solve problems such as not being able to feel good and patients not being able to move well

Inactive Publication Date: 2009-06-03
VANDA PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] A less severe type of depression, dysthymia, involves long-term chronic symptoms that do not cause incapacity but prevent the sufferer from being able to function well or feel well

Method used

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  • Treatment for depressive disorders
  • Treatment for depressive disorders
  • Treatment for depressive disorders

Examples

Experimental program
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Effect test

Embodiment 1-3

[0124] Example 1-3 . MA-1 was tested in the following 3 models: (1) stress-induced cGMP elevation, (2) mouse forced swim test and (3) rat forced swim test. The following are the experimental protocols used and the results obtained from these studies.

[0125] Stress-induced cerebellar cGMP elevation

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Abstract

The present invention provides a method for treating a depressive disorder which comprises a dministering a melatonin agonist alone, or in combination wit additional ant idepressant medication(s). The depressive disorder treated is one or more of major depression, dysthymia or bipolar disorder. A kit is also provided com prising one or more pharmaceutical dose units of a melatonin agonist and oneor more pharmaceutical dose units of an antidepressant. The individual dose .units may each further comprise an antidepressant or antipsychotic, and opt ionally one or more pharmaceutically active ingredients.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of co-pending US Provisional Patent Application Serial No. 60 / 747,843, filed May 22, 2006, which is hereby incorporated into this application. technical field [0003] The present invention belongs to the field of drug treatment of depressive diseases. Background technique [0004] Depressive disorders affect nearly 20 million adults in the United States alone. Depressive disorders can be emotionally and physically debilitating if left untreated. [0005] Depressive disorders include a spectrum of symptoms listed in a brochure published by the U.S. National Institute of Mental Health (NIMH) entitled "Depression" as follows: [0006] "Persistent sadness, anxiety, or 'empty' feelings [0007] despair, pessimism [0008] Guilt, worthlessness, helplessness [0009] Loss of interest or pleasure in hobbies and activities (including sex) that you once enjoyed [0010] Decreased energy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/02
CPCA61K31/405A61P25/00A61P25/04A61P25/18A61P25/20A61P25/24A61P3/04A61P43/00C07D307/02
Inventor G·比兹尼克斯D·费德克M·H·波利梅罗波洛斯
Owner VANDA PHARMA INC
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