Diabetes-treating medicament Gliclazide tablet convenient for dividing dose and method for producing the same

A technology for diabetes drugs and production methods, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of complex processes and high manufacturing costs, and achieve simple processes, low production costs, and accurate dosage Effect

Inactive Publication Date: 2009-05-27
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It provides convenience for patients, especially the elderly, and some high-precision dosage needs, and its production method solves the problems of complicated process and high manufacturing cost of existing similar tablets

Method used

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  • Diabetes-treating medicament Gliclazide tablet convenient for dividing dose and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Gliclazide tablets (80mg / tablet), in terms of 1000 tablets, its formula is:

[0045] Raw material name Weight (unit: gram)

[0046] Gliclazide 80 (fold scalar)

[0047] Starch 70

[0048] Sodium carboxymethyl starch 8

[0049] Slurry starch 8 (add appropriate amount of purified water to make 8% starch slurry)

[0050] Magnesium Stearate 1

[0051] The production method is as follows: after mixing gliclazide with 100-mesh starch and carboxymethyl starch sodium, add 8% starch slurry to make soft material, 16-mesh sieve to make granules, and dry the wet granules in a boiling dryer. 60-70°C, drying time about 30-40 minutes, sieve the dry granules with a 16-mesh sieve, add 80-mesh magnesium stearate and mix evenly, test the content to determine the tablet weight, use flat cross punching tablets, and pack.

Embodiment 2

[0053] Gliclazide tablets (80mg / tablet), in terms of 1000 tablets, its formula is:

[0054] Raw material name Weight (unit: gram)

[0055] Gliclazide 80 (fold scalar)

[0056] Starch 60

[0057] Dextrin 10

[0058] Crystalline Cellulose 8

[0059] Slurry starch 8 (add appropriate amount of purified water to make 8% starch slurry)

[0060] Magnesium Stearate 1

[0061]The production method is: mix gliclazide with 100 mesh starch, dextrin, and crystal cellulose, add 8% starch slurry to make soft material, 16 mesh sieve to make granules, and dry the wet granules in a boiling dryer , the temperature is 60-70°C, the drying time is about 30-40 minutes, the dry granules are sieved with a 16-mesh sieve, and the 80-mesh magnesium stearate is added and mixed evenly. .

Embodiment 3

[0063] Gliclazide tablets (80mg / tablet), in terms of 1000 tablets, its formula is:

[0064] Raw material name Weight (unit: gram)

[0065] Gliclazide 80 (fold scalar)

[0066] Starch 50

[0067] Dextrin 20

[0068] Sodium carboxymethyl starch 5

[0069] Low-substituted hydroxypropyl cellulose 3

[0070] Slurry starch 8 (add appropriate amount of purified water to make 8% starch slurry)

[0071] Magnesium Stearate 1

[0072] The production method is as follows: after mixing gliclazide with 100-mesh starch, dextrin, sodium carboxymethyl starch, and low-substituted hydroxypropyl cellulose, add 8% starch slurry to make soft material, and 16-mesh sieve to make granules . The wet granules are dried in a boiling dryer at a temperature of 60-70°C, and the drying time is about 30-40 minutes. The dry granules are sieved with a 16-mesh sieve, added with 80-mesh magnesium stearate and mixed evenly. The content is determined to determine the tablet weight. It adopts flat cross stamp...

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Abstract

The invention relates to a medicine treating diabetes-gliclazide tablet which is convenient for distributing dose and a production method. The gliclazide tablet comprises gliclazide, filler, disintegrant and lubricant. The invention adopts the production method that after the gliclazide, the filler and the disintegrant which are of 80 meshes or 100 meshes are mixed, soft materials and particles are made by adding adhesive, dryness and pelletization are carried out by adding the adhesive, uniform mixing is carried out after the lubricant is added, the tablet weight is ensured by testing content, a flat cross stamping tablet is adopted, and the gliclazide tablet can be obtained by packing. On the one hand, the invention solves the problems of accurate tablet and convenient dose distribution, and can conveniently divides the tablet into a one half tablet and a one fourths tablet; on the other hand, the invention solves the problems of the prior same tablet of complex process and high manufacture cost, saves the medicine cost and medicine resources, and finally lowers the therapy cost of a diabetic patient.

Description

technical field [0001] The invention relates to a medicine for treating diabetes, in particular, a kind of medicine for treating diabetes which is convenient to be divided into doses—gliclazide tablet and a production method thereof. Background technique [0002] Diabetes is the second most common disease in the world after cardiovascular disease, and there are currently hundreds of millions of patients. In my country, mainly type II diabetes patients are in the majority, and there are more than 30 million middle-aged and elderly patients over 50 years old who have been diagnosed with type II diabetes through clinical diagnosis. With the improvement of people's living standards, the prevalence of diabetes has increased rapidly, especially obese type II diabetes patients have increased significantly, and tend to be younger. [0003] The current treatment of type II diabetes is divided into diet and exercise therapy, insulin therapy and oral hypoglycemic drugs. Diet and exer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/403A61P3/10
Inventor 余定祥
Owner SICHUAN MEDCO PHARML
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