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Method for extracting alkannin from alkanet

A technology of shikonin and shikonin, which is applied to pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of low efficiency, long time consumption, limited scope of use, etc., and achieves simple process flow and energy consumption. The effect of less and lower production cost

Inactive Publication Date: 2009-05-20
NORTHEAST FORESTRY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method can only use fresh comfrey raw materials, and the raw materials must be processed quickly after picking, or strict fresh-keeping measures must be taken, and the scope of application is limited. In addition, the raw materials need to be soaked in solvent ethanol before liquid crushing, which takes a long time and is inefficient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 50g of dried comfrey root and place it in a homogenizer, add 500ml of 90% ethanol solution to homogenate and extract for 4min according to the ratio of material to liquid at 1:10, the rotation speed of the homogenizer is 8000 rpm, filter the mixture under reduced pressure, and then add 500ml90 of the solid % ethanol solution was extracted for 4 min, the extracts were combined after solid-liquid separation, and concentrated under reduced pressure at 55°C to obtain 0.82 g of shikonin crude product with a purity of 3.19%.

Embodiment 2

[0020] Take dried comfrey root 500g and place it in a homogenizer, add 5000ml of 80% ethanol solution to homogenate and extract for 5min according to the ratio of material to liquid at 1:10, and the homogenizer rotates at 4000 rpm, and the obtained mixture is filtered under reduced pressure, and the solid is re- Add 3000ml of 80% ethanol solution for extraction for 5 minutes, combine the extracts after solid-liquid separation, and concentrate under reduced pressure at 55°C to obtain 8.43g of shikonin crude product with a purity of 2.95%.

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PUM

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Abstract

The invention discloses a method for extracting alkannin from alkanet, which is characterized in that the alkanet is mixed with an aqueous solution containing alcohol in accordance with a certain ratio of material to liquid and put into a pulp refiner for homogenate extraction. Solid-liquid separation is carried out to a mixture obtained after the homogenate to obtain an extracting solution. Solid contents are then mixed with the aqueous solution containing alcohol according to a certain ratio of material to liquid and put into the pulp refiner for the homogenate extraction to obtain an extracting solution. The extracting solutions are merged and then decompression condensed to obtain a crude product of alkannin. The operation technology is mainly characterized by smooth process, simple operation, extraction at room temperature for avoidance of the degradation of alkannin, recyclable reagents used, low energy consumption, low production costs and high yield.

Description

Technical field: [0001] The invention relates to the field of natural product chemistry, in particular to a method for extracting shikonin from shikonin roots. [0002] The main features of this operation process are smooth process, simple operation, extraction at normal temperature avoids shikonin degradation, recyclable reagents used, less energy consumption, low production cost and high yield. Background technique: [0003] As the main medicinal ingredient of comfrey, shikonin has various pharmacological effects such as hemostasis, antibacterial, anti-inflammatory, anti-tumor, immune regulation, anti-oxidation, and liver protection. It is widely used clinically to treat skin diseases such as psoriasis, erythema nodosum, and wet macule; it also has good curative effects in burns, acute hepatitis B, and gynecology. Both shikonin and its derivatives have active groups such as the 5,8-position phenolic hydroxyl group, double bonds and ester bonds on the side chain, and the s...

Claims

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Application Information

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IPC IPC(8): C07C50/32C07C46/10A61K36/30
Inventor 祖元刚杨磊张琳刘婷婷王化祖柏实赵春建杨逢建孙志强
Owner NORTHEAST FORESTRY UNIVERSITY
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