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Therapeutic compositions containing amlodipine niacin and rosuvastatin medicament

A technology of amlodipine and nicotinic acid ammonium chloride, applied in the direction of drug combination, medical preparations containing active ingredients, active ingredients of heterocyclic compounds, etc., can solve the problem of amlodipine besylate without light resistance, ammonium besylate Lodipine has no solubility, amlodipine has slow onset of action and other problems

Inactive Publication Date: 2009-05-20
BEIJING ROCK PHARMA
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  • Abstract
  • Description
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Problems solved by technology

[0014] However, amlodipine besylate does not have good enough solubility in water. As everyone knows, amlodipine itself has the weakness of slow onset of action, which will further affect the bioavailability and onset time of amlodipine. In addition, benzene Amlodipine sulfonate does not have sufficient photostability

Method used

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  • Therapeutic compositions containing amlodipine niacin and rosuvastatin medicament
  • Therapeutic compositions containing amlodipine niacin and rosuvastatin medicament
  • Therapeutic compositions containing amlodipine niacin and rosuvastatin medicament

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Embodiment Construction

[0038] The present invention relates to a pharmaceutical composition containing amlodipine niacin and / or a statin compound or a pharmaceutically acceptable salt thereof.

[0039] Amlodipine can be easily prepared according to the method described in US Patent 4,572,909, which is incorporated herein by reference. Amlodipine niacin can be easily prepared according to the method described in Chinese Patent CN00,124,812, which is hereby incorporated by reference. Amlodipine and amlodipine niacin are both effective and long-acting calcium channel blockers.

[0040] The "statin" compound refers to lovastatin, pravastatin, simvastatin, fluvastatin and atorvastatin or a pharmaceutically acceptable salt thereof, preferably atorvastatin and its calcium salt.

[0041] Lovastatin, pravastatin, simvastatin, and fluvastatin can be easily prepared by the methods described in U.S. Patent Nos. 4,342,767, 4,346,227, 4,444,784, and 4,739,073, respectively, which are incorporated herein by reference....

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Abstract

The invention relates to a pharmaceutical composition containing amlodipine besylate, and a statins compound or a pharmaceutically acceptable salt thereof, a preparation method and a medicine box for drug combination of the medicine composition. The composition comprises the following components: a) a certain amount of the amlodipine besylate; b) a certain amount of one or more statins compounds or pharmaceutically acceptable salts thereof; and c) a pharmaceutically acceptable carrier or a diluting agent. The composition or the medicine box can be used for treating patients suffering from angina pectoris, atherosclerosis and / or accompanied hypertension and hyperlipoidemia, and treating patients (including human beings) having heart risky symptoms.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition of amlodipine nicotinate and a statin compound or a pharmaceutically acceptable salt thereof and a preparation method thereof. The present invention also relates to a medicine kit containing a combined medication of amlodipine nicotinate and a statin compound. The above-mentioned composition or kit can be used to treat patients suffering from angina pectoris, atherosclerosis, and / or hypertension and hyperlipidemia, and patients (including humans) with dangerous cardiac symptoms. Background technique [0002] With the changes in the structure of human diseases, diseases caused by hyperlipidemia have become enemies that threaten health. Every year, 8-10 million people die from cardiovascular disease and stroke in the world. Arteriosclerosis caused by hyperlipidemia is the main cause of coronary heart disease, hypertension, and cerebrovascular disease. The main component of coronary atherosclerotic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K31/40A61K31/366A61K31/405A61K31/22A61P9/10A61P9/12
CPCA61K31/505A61K31/22A61K9/06A61K31/4422A61K31/40A61P3/06A61P9/10A61P9/12
Inventor 王海勇陈艳明付俊昌王雷波
Owner BEIJING ROCK PHARMA
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