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Uses of rhodiola rosea plants in medicament for preventing and treating diabetes and adiposis

A technology for Rhodiola rosea and diabetes, which is applied in the application field of Rhodiola rosea plants to prevent and treat diabetes and obesity, and can solve the problems of large systemic side effects and difficult dosage control.

Inactive Publication Date: 2009-05-13
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large side effects of the cardiovascular system and other systemic side effects of these drugs, and the difficulty in controlling the dose, these drugs have been rarely used clinically.

Method used

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  • Uses of rhodiola rosea plants in medicament for preventing and treating diabetes and adiposis
  • Uses of rhodiola rosea plants in medicament for preventing and treating diabetes and adiposis
  • Uses of rhodiola rosea plants in medicament for preventing and treating diabetes and adiposis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Roots and rhizomes of Rhodiola rosea are taken as raw materials, sliced ​​and dried, crushed into coarse powder, the coarse powder is reflux extracted with 40-95% ethanol, the extract is filtered, concentrated and dried to obtain Rhodiola rosea extract. Concrete method: 1) take 200g of dry rhizomes of Rhodiola rosea, add 1500ml of 95% ethanol, extract under reflux for 45 minutes, cool, pour out the ethanol extract; and extract twice under the same conditions. The combined extracts were concentrated by a rotary evaporator to 200 ml under reduced pressure, and the concentrated solution was freeze-dried to obtain 42 g of a yellow-brown blocky extract.

Embodiment 2

[0055] The roots and rhizomes of Rhodiola rosea were sliced ​​and dried, then crushed into coarse powder. Take 200g, add 1500ml of 75% ethanol, extract under reflux for 45 minutes, cool, and pour out the ethanol extract; under the same conditions, extract twice. The extracts were combined, concentrated to 200 ml by a rotary evaporator under reduced pressure, and the concentrate was freeze-dried to obtain 45 g of a yellow-brown blocky extract.

Embodiment 3

[0057] The roots and rhizomes of Rhodiola rosea are used as raw materials, sliced ​​and dried, and then crushed into coarse powder. The coarse powder is extracted with water as a solvent, refluxed, filtered, concentrated, and dried to obtain the Rhodiola rosea extract. Specific methods: 1) Take 100 g of dried rhizome of Rhodiola rosea, add 1500 ml of water, extract under reflux for 45 minutes, cool, pour out the water extract; and extract twice under the same conditions. The combined extracts were concentrated by a rotary evaporator to 200 ml under reduced pressure, and the concentrated solution was freeze-dried to obtain 28 g of a yellow-brown blocky extract.

[0058] Pharmacological experiment

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Abstract

The invention discloses a Rhodiola L. and the application of the extract thereof as the drug for preventing and curing the impaired glucose tolerance / diabetes, adiposis and the relative metabolic diseases; meanwhile, the invention discloses a preparation method for the extract; in addition, the invention further discloses the application of a pharmaceutical composition including the Rhodiola L. and the Rhodiola L. extract, and particularly discloses the application of the pharmaceutical composition used for preparing the drugs and the health-care products for curing and preventing the impaired glucose tolerance / diabetes, adiposis and the relative metabolic diseases.

Description

technical field [0001] The present invention relates to extracting an extract from plants of the genus Rhodiola, which has α-glucosidase inhibitory effect and can resist impaired glucose tolerance / diabetes and obesity and related metabolic diseases. The preparation method of this extract comprises Pharmaceutical compositions of Rhodiola plants or extracts of the genus, and uses of plants of the genus Rhodiola or extracts of the genus and pharmaceutical compositions thereof, especially for the preparation of treatments and prevention of impaired glucose tolerance / diabetes and obesity The use of drugs and health products for metabolic diseases and related metabolic diseases. Background technique [0002] Metabolic syndrome is a series of chronic diseases, including impaired glucose tolerance / type 2 diabetes and its complications, obesity, dyslipidemia, non-alcoholic fatty liver, coronary heart disease and other clinical abnormalities. After that, it is the third major disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P3/10
Inventor 叶菲张培成田金英冯子明陶荣亚丛维娜刘倩吴倩牛亚景杨桠楠金晶
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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