Biological degradable hydroxyapatite artificial bone and preparation method thereof

Abstract

The invention provides a microcapsule food preservative, belonging to the technical field of medical biomaterials, in particular to a bioactivity degradable hydroxylapatite artificial bone and a preparation method thereof. Degradable hydroxylapatite is used as a bracket material and composed with cytokine human bone morphogenetic protein-2 mature peptide with strong bone-inducing activity. The preservative takes natural coral as a raw material, is obtained by hydrothermal reaction and realizes the controllability of the degradation time by controlling the reaction degree; and the degradation time inside the artificial bone is one year, the coral hydroxylapatite used as a bone graft material has excellent bone conduction activity and human bone morphogenetic protein-2 mature peptide with strong bone-inducing activity is composed, therefore, the artificial bone has bone conduction and bone-inducing activity required by regeneration of new bone, can quicken the healing of the bone, can be gradually absorbed during the forming process of self-bone, has extremely obvious bone graft effect and is an excellent bone-substitute.

Description

Technical field: [0001] The invention belongs to the technical field of medical biomaterials, in particular to a bioactive degradable hydroxyapatite artificial bone and a preparation method thereof. Background technique: [0002] Patients with bone defects account for a high proportion of orthopedic patients. These patients cannot repair the defect through the body's own recovery mechanism, so bone transplantation must be performed. At present, the methods mainly used in clinical bone defect repair include autologous bone grafting and allogeneic bone grafting, but autologous bone grafting has problems such as limited material sources, damage to the bone donor site, and difficulty in shaping; allogeneic bone grafting also has potential risks of disease transmission As well as serious consequences such as graft rejection, neither autologous bone graft nor allogeneic bone graft can fully meet the demand, and the severe shortage of graft materials has become a problem that has p...

AI Technical Summary

Problems solved by technology

Coral and coral-derived hydroxyapatite materials have a pore structure similar to that of human bone, and are widely used as scaffold materials for filling bone defects. Because of their good three-dimensional structure and biomechanical properties, they perform excellent Osteoconduction activity, but the ability to induce new bone is insufficient, and the osteogenesis process is slow, especially for large segmental bone defects and large area bone defects, it cannot achieve satisfactory curative effect

In addition, the main component of coral CaCO 3 , implanted in the body is quickly degraded, not enough to maintain the entire bone formation process, while hydroxyapatite degrades very slowly in the body, affecting the replacement of its own tissues; bone morphogenic protein-2 has the strongest ability to induce bone formation in the body One of the most common cytokines, BMP-2, can accelerate fracture healing and new bone formation, but BMP-2, as a small molecular protein, lacks a stable mechanical structure and is easy to diffuse, so it cannot Therefore, although cytokines have good osteoinductive activity, they still cannot play a significant role in the repair of bone defects when used alone

Therefore, for tissue engineered artificial bone, the use of a single element has been difficult to meet the clinical demand for bone graft substitutes. The current research and application have gradually turned to the compound use of multiple elements to build a more effective and reasonable artificial bone. bone