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A composition and drug technology, applied in the direction of antineoplastic drugs, drug combinations, medical preparations containing active ingredients, etc., can solve the problems of severe toxicity, heat generation and toxicity
Active Publication Date: 2012-10-03
北京九龙制药有限公司
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In addition, modern Western medicine chemotherapy and radiotherapy are used to treat accumulation of lumps, and the medicines used are all highly toxic, which is enough to consume righteousness and generate heat toxins.
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Embodiment 1
[0031] Embodiment 1: the preparation of capsule
[0032]Take artificial bear bile, artificial musk, astragalus, frankincense, myrrh, Chonglou, Panax notoginseng, artificial bear bile, artificial musk and grind them into fine powder; Astragalus and Chonglou (weight ratio 400:200) are combined and extracted with 10 times the amount of water 2 times, 1 hour each time, the extract was concentrated and dried; frankincense, myrrh, and Panax notoginseng (weight ratio 200:200:200) were combined and refluxed with 10 times of ethanol for 2 times, 1 hour each time, the extract was concentrated , dry; mixed in proportion (weight ratio is artificial bear bile 40; artificial musk 10; combined extract of Astragalus and Pachyphylla 300; 300 combined extract of frankincense, myrrh, and Panax notoginseng), adding dextrin and starch (extract- The ratio of dextrin-starch is 6:2:2), granulated with 80% alcohol, dried, sized, and packed into capsules.
Embodiment 2
[0033] Embodiment 2: the preparation of powder
[0034] Get artificial bear bile, artificial musk, Astragalus membranaceus, frankincense, myrrh, Chonglou, Panax notoginseng, pass through a 120 mesh sieve after crushing respectively, and mix evenly (weight ratio is artificial bear bile 33; artificial musk 12; astragalus 500; frankincense 300; Myrrh 300; Chonglou 300; Panax notoginseng 300).
Embodiment 3
[0035] Embodiment 3: the preparation of granule
[0036] Take artificial bear bile and artificial musk and grind them into fine powder; Astragalus membranaceus and Chonglou are extracted with water respectively, frankincense, myrrh and Panax notoginseng are respectively extracted with ethanol reflux, and mixed according to the following weight ratio: artificial bear bile 45; artificial musk 8; astragalus Extract 200; Frankincense Extract 100; Myrrh Extract 100; After mixing, add dextrin and starch (the ratio of composition-dextrin-starch is 6:2:2), granulate with 70% alcohol, dry, granulate, and pack into bags.
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Abstract
The invention relates to a drug combination with an antineoplastic function, which comprises artificial bear gall, artificial musk, astragalus hoangtchy, boswellia carteri, myrrh, rhizoma paridis and radix pseudoginseng and can obviously control the growth of transplantation tumor MGC-803 of S180 tumor-bearing mice and BALB / C mice. Composition of stomach is filled in a rat and cyclophosphamidum is injected into an abdominal cavity so as to prolong the survival time of S180 mice with ascites tumor. When used with the cyclophosphamide, the composition of stomach has a synergy trend for the survival time of S180 mice with ascites, a certain improvement for immune function reduction caused by the injection of cyclophosphamidum and a certain enhancement for phagocytic clearance capacity of carbon granules, and increases pyagocytic index (K) and contents of serum hemolysin. The drug combination can be used for the treatment of primary gastric cancer, block blood poisoning of traditional Chinese medicine and righteousness weak disorder, and can be prepared as drugs or health food with antineoplastic drugs, food and health products.
Description
technical field [0001] The invention relates to a pharmaceutical composition with antitumor effect, which is composed of artificial bear bile, artificial musk, astragalus, frankincense, myrrh, pachyrhiza and notoginseng. Can significantly inhibit S 180 The growth of tumor-bearing mice and BALB / C mice with MGC-803 xenograft tumors, intragastric administration of the composition and intraperitoneal injection of cyclophosphamide can prolong the S 180 Survival time of mice with ascites tumor, combined with cyclophosphamide on S 180 There was a tendency for a synergistic effect in the survival time of ascites mice. It can improve the immune function reduction caused by injection of cyclophosphamide and enhance the phagocytosis and clearance of carbon particles in the blood stream. Improve phagocytosis index (K), increase serum hemolysin content. The composition can be used for the treatment of primary gastric cancer, TCM stagnation of toxin and blood stasis, deficiency of vital...
Claims
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