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Chitosan spherical honeycombed grain material, producing method and apparatus thereof

A technology of porous particles and spherical particles, applied in dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problems of high packing density, large diameter distribution range of microspheres, unfavorable new tissue growth, etc., and achieve uniform particle size good, flow-friendly effect

Inactive Publication Date: 2012-11-28
JIANGSU HAIJIAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microspheres prepared by these methods have a large diameter distribution range and a high packing density. When applied to tissue filling, the pores between the particles are too small, which is not conducive to the growth of new tissues.

Method used

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  • Chitosan spherical honeycombed grain material, producing method and apparatus thereof
  • Chitosan spherical honeycombed grain material, producing method and apparatus thereof
  • Chitosan spherical honeycombed grain material, producing method and apparatus thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) be that the acetic acid solution preparation chitosan quality of 1.5% with mass concentration accounts for the chitosan acetic acid solution of whole chitosan acetic acid solution quality 6%, stirring fully makes chitosan dissolve completely;

[0028] (2) if figure 1 Shown, the prepared chitosan acetic acid solution is added to the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by a pressure control valve and a pressure gauge to be 0.08MPa to make the chitosan acetic acid solution from the pipe diameter of The catheter 6 of φ0.5mm flows out evenly at a speed of 10 drops / min, and the flow rate is controlled by the flow control valve. The chitosan acetate solution flowing out of the catheter grows to a nearly spherical shape of about φ0.8mm at the mouth of the tube. After the particles are dripped, they are dripped into the condensate 7 at a temperature of -10°C in the heat preservation container 8 to condense, and the con...

Embodiment 2

[0031] (1) be that the acetic acid solution preparation chitosan quality of 3% with mass concentration accounts for the chitosan acetic acid solution of whole chitosan acetic acid solution quality 25%, stirring fully dissolves;

[0032] (2) the prepared chitosan acetic acid solution is added to the storage tank 4 from the feeding port 1, and the pressure in the control storage tank 4 is 0.5MPa to make the chitosan acetic acid solution from the pipe diameter be the catheter tube 6 of φ 3mm Flow out evenly at a speed of 60 drops / min, and the chitosan acetic acid solution flowing out from the catheter grows to a nearly spherical particle of about φ4mm at the mouth of the tube and then drips. The condensate 7 is condensed to form a spherical particle material; the condensate is vegetable oil.

[0033] (3) The condensed microspheres are separated, and freeze-dried at a temperature of -10°C for 24 hours. The spherical particles after the freeze-drying are first put into a glyoxal so...

Embodiment 3

[0035] (1) be that the acetic acid solution preparation chitosan quality of 5% with mass concentration accounts for the chitosan acetic acid solution of whole chitosan acetic acid solution quality 15%, stirring fully dissolves;

[0036] (2) the prepared chitosan acetic acid solution is added to the storage tank 4 from the feed port 1, and the pressure in the control storage tank 4 is 0.28MPa to make the chitosan acetic acid solution from the pipe diameter to be φ 1.5. Tube 6 flows out evenly with the speed of 30 drops / min, and the chitosan acetic acid solution that flows out from catheter tube grows to the subspherical particle of about φ 2mm at the mouth of the pipe and then drips, and the temperature that drips in the heat preservation container 8 is- Condensation in the condensate 7 at 15°C to form spherical granular materials;

[0037] (3) The condensed microspheres are separated, and freeze-dried at a temperature of - (5 ~ 10) ° C for 14 hours. The spherical particles aft...

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Abstract

The invention relates to a chitosan spherical porous particle material, and a method and a device for preparing the same. The method comprises the following steps: step one, preparing a chitosan acetic acid solution by using an acetic acid solution, wherein the mass concentration of the acetic acid solution is between 1 and 5 percent, and the mass of the chitosan is between 5 and 25 percent of the total mass of the chitosan acetic acid solution; step two, adding the solution into a material storage tank from a feed opening, and controlling the pressure in the material storage tank between 0.08 and 0.5 Mpa through a pressure meter and a pressure control valve, wherein the chitosan acetic acid solution uniformly flows out of the material storage tank at a speed of between 10 and 60 drops per minute, and then is dripped into a condensate with a temperature between 10 and 20 DEG C below zero in a thermal insulation container to be condensed, so that a collagen spherical porous particle material with good sphericity and uniform particle diameter is formed; and step three, separating, freezing, drying, crosslinking and cleaning the collagen spherical porous particle material to obtain the chitosan spherical porous particle material. The spherical particle material has homogeneous particle diameter distribution, contains a large number of micropores communicated with one another therein, has higher specific surface area, and can be applied to tissue repair and medicament slow release.

Description

1. Technical field [0001] The invention belongs to a preparation technology of a spherical granular material applied in the field of biomedicine, and in particular relates to a preparation method of a natural polymer chitosan spherical porous granular material. 2. Background technology [0002] Existing technology: Chitin widely exists in the shells of arthropods such as shrimps, crabs and insects, and in the cell walls of lower plants such as bacteria and algae. It is one of the most abundant biopolymers in nature and is an extremely rich natural compound. recycled resources. Chitosan is the deacetylation product of chitin. Chitosan is non-toxic, biocompatible and biodegradable. In recent years, it has been used as a natural medical polymer material in absorbable surgical sutures, hemostatic materials, wound dressing materials and Research on artificial skin and other aspects is very eye-catching. At the same time, chitosan is also an excellent hard tissue repair material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/56A61K6/097A61K6/898
Inventor 董寅生浦跃朴储成林盛晓波郭超林萍华
Owner JIANGSU HAIJIAN
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