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Wild Jinchai liveness extract, preparation and uses thereof

The technology of an extract and Jinchai is applied in an active extract of wild Jinchai and its application field, which can solve the problem of no preparation, etc., and achieve the effect of simple and convenient production process and rich raw materials

Inactive Publication Date: 2009-04-08
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Many researches on the chemical constituents and pharmacological effects of the leaves of Glycyrrhiza polycarpa are limited to the research on health-care tea, beverage and its sweetness components. Wild Jinchai, which has three economic values ​​of tea, sugar and medicine, The efficacy of its "medicine" needs to be developed urgently, but there are fewer research reports on this aspect of Jiangxi Yejinchai, and there are no reports on preparations

Method used

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  • Wild Jinchai liveness extract, preparation and uses thereof
  • Wild Jinchai liveness extract, preparation and uses thereof
  • Wild Jinchai liveness extract, preparation and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 5kg of Wild Jinchai medicinal material is crushed into particles with a particle size of less than 10mm by crushing machinery, adding 20 times the amount of water, stirring to keep dynamic, and under the condition of 0°C to 5°C, through "normal pressure-vacuum-adding solvent- Atmospheric pressure-increased pressure-normal pressure”continuously circulates for differential pressure extraction, the vacuum degree is maintained at 14Pa, the pressure is maintained at 10.00MPa, and 4 cycles of extraction are performed. The extract is subjected to solid-liquid separation by a solid-liquid separation machine until it is clarified to obtain a clarified extract, which is continuously subjected to microfiltration and ultrafiltration to obtain a concentrate, and spray-dried to obtain the total extract of Chai Chai. Taking naringin as the reference substance, the total flavonoid content in the active extract of Yejinchai was determined to be about 60% by ultraviolet spectrophotometry....

Embodiment 2

[0043] Take 5kg of wild Jinchai medicinal material, crush it into particles with a particle size below 10mm by crushing machine, add 20 times the amount of process water, stir to keep dynamic, at 0°C to 5°C, "normal pressure-vacuum-add solvent-normal pressure -Pressure-atmospheric pressure"continuously circulates for differential pressure extraction, the vacuum degree is maintained at 14Pa, the pressure is maintained at 10.00MPa, and 4 cycles of extraction are performed. The extract is subjected to solid-liquid separation by a solid-liquid separation machine until it is clarified to obtain the extract. Take 200ml of the extract, add an equal amount of water to dilute, pass through AB-8 macroporous adsorption resin, wash with water until colorless, elute with 70% ethanol until colorless, collect the eluate, concentrate under reduced pressure until there is no alcohol smell, and dry Get the active extract of wild Jinchai. Taking naringin as the reference substance, the total fl...

Embodiment 3

[0045] Take 5kg of wild Jinchai medicinal material, crush it into particles with a particle size below 10mm by crushing machine, add 20 times the amount of process water, stir to keep dynamic, at 0°C to 5°C, "normal pressure-vacuum-add solvent-normal pressure -Pressure-atmospheric pressure"continuously circulates for differential pressure extraction, the vacuum degree is maintained at 14Pa, the pressure is maintained at 10.00MPa, and 4 cycles of extraction are performed. The extract is subjected to solid-liquid separation by a solid-liquid separation machine until it is clarified to obtain the extract. Take 200ml of the extract, add an equal amount of water to dilute, pass through a polyamide column (30-60 mesh), wash with water until colorless, elute with 80% ethanol until colorless, collect the eluate, concentrate under reduced pressure until no alcohol smell , and dried to obtain the active extract of Wild Jinchai. Taking naringin as the reference substance, the total flav...

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Abstract

The invention relates to a wild Jinchai extract, as well as a preparation method and application thereof. In the wild Jinchai active extract, the Jiangxi wild Jinchai beech family plant, namely the Lithocarpus polystachyus (wall) Rehd or L.litseifolius (Hamce) Chun is used as a raw material; one of a low-temperature differential pressure type extraction method, a solvent extraction method, a macropore adsorptive resin method, a column chromatography method, a membrane separation concentration technique, a spray drying technique and a freeze drying technique or the free combination of the methods is adopted to prepare the extract. The invention is characterized in that a modernly advanced low-temperature differential pressure type extraction technique is matched with the membrane separation concentration technique and the spray drying technique to prepare the wild Jinchai active extract; and the macropore adsorptive resin technique and the polyamide separation enrichment technique are matched with the freeze drying technique to prepare a wild Jinchai total flavone extract. The content of the total flavone in the wild Jinchai active extract is between 10 and 90 percent, and the pharmacological activity of the wild Jinchai active extract on protecting liver, reducing fat and resisting type 2 diabetes and diabetic complication is higher than that of the prior aqueous extract and alcohol extract.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, and in particular to an active extract of Yejinchai and its application. technical background [0002] The sources of wild golden wood mainly include the young shoots and leaves of plants such as wild golden wood of Rosaceae, hydrangea family Tuchangshan, Fagaceae Dustia, and grape family Vitaceae. The wild Jinchai referred to in the present invention, also known as wild Jinchai, is mainly derived from the entire plant or any part of the Fagaceae plant Lithocarpus polystachyus (wall) Rehd or L.litseifolius (Hamce) Chun. in Jiangxi, such as the root , rhizomes, stems, leaves, flower spikes, etc. In the wild state, Shike is distributed in the low mountains and dense forests above 400 meters above sea level in the provinces south of the Yangtze River. Especially Jiangxi, Guangxi, Hunan, Anhui and other provinces are rich and concentrated in resources, Guangdong, Yunnan, Sichuan, Fujian ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/00A23L1/29A61P17/02A61P17/04A61P1/12A61P9/10A61P9/12A23L33/00
Inventor 黄松曾峰宇侯少贞陶艳蒋东旭谢友良冼小敏陈吉航赖小平陈建南
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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