Novel use of antihistamine agents for the preventive or early treatment of inflammatory syndromes, in particular those triggered by togaviruses

Abstract

The present invention relates to the use of at least one antihistamine agent for the preparation of a medicament for use in the preventive or early treatment of inflammatory syndromes of viral origin, in particular arthritis of the distal joints, more particularly those triggered by togaviruses. The invention also relates to a combination product of at least one antihistamine agent and of at least one antiserotonin agent for its simultaneous, separate or sequential use in preventive or early therapy for inflammatory syndromes of viral origin, in particular arthritis of the distal joints, more particularly those triggered by togaviruses.

Description

technical field [0001] The present invention relates to a new application of antihistamines in the preparation of pharmaceutical products for the prevention or early treatment of inflammatory syndromes, especially arthritis caused by viral origin. Background technique [0002] In general, following a localized or diffuse attack on tissue, whether caused by trauma or infection, the body engages in a complex cascade of reactions to clear the infection and initiate repair processes. This sequence of events is called the inflammatory response and links the local phenomenon with the generation of systemic signals. The inflammatory cascade can be initiated for many reasons: bacterial, viral, parasitic, fungal, neoplastic, traumatic, physical and / or immunological. Systemic, biological, and clinical abnormalities identified at this time form the inflammatory response syndrome. Cytokines produced by macrophages play a central role in coordinating the mechanisms by which inflammator...

AI Technical Summary

Problems solved by technology

Antibiotics are used for infectious arthritis caused by bacterial sources, but for arthritis caused by viruses, the etiological treatment is generally not prescribed