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Slowly released type antibiotic medical catheter and preparation method thereof

A medical catheter and slow-release technology, applied in catheters and other directions, to achieve the effect of high silver loading, saving medical resources and good safety

Inactive Publication Date: 2009-02-11
HUADONG HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are products on the market (products of Shanghai Runhe Nano Material Technology Co., Ltd.), but so far there has been no report on the preparation of antibacterial medical catheters using phosphate as a carrier of silver-based inorganic antibacterial agents

Method used

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  • Slowly released type antibiotic medical catheter and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1. prepare PU central vein antibacterial medical catheter

[0031] 1. Preparation of PU antibacterial plastic masterbatch

[0032] Blend 1 kg of zirconium phosphate silver-loaded antibacterial powder with a silver loading of 4% and 3 kg of barium sulfate powder, then add it to 6 kg of PU resin, blend and extrude to obtain a silver-containing inorganic antibacterial powder with a content of 10% PU antibacterial plastic masterbatch.

[0033] 2. Preparation of Central Venous Catheter

[0034] Blend 5 kg of PU antibacterial plastic masterbatch with 45 kg of PU raw material, and pass through the relevant tube-making process as usual to prepare a central venous antibacterial medical catheter.

Embodiment 2

[0035] Embodiment 2. prepare antibacterial urinary catheter

[0036] 1 kg of zirconium phosphate silver-loaded antibacterial powder with a silver loading of 6% was blended with 99 kg of PVC powder, fully mixed evenly, and an antibacterial urinary catheter was obtained through a catheter production process as usual.

Embodiment 3

[0037] Embodiment 3. prepare PVC antibacterial catheter

[0038] 1. Preparation of PVC antibacterial masterbatch:

[0039] 1 kg of zirconium phosphate silver-loaded antibacterial powder with a silver loading of 10% was blended with 4 kg of PVC particles, and through a twin-screw extrusion process, an antibacterial PVC masterbatch with a silver-based inorganic antibacterial powder content of 20% was obtained.

[0040] 2. Preparation of antibacterial urinary catheter: 5 kg of antibacterial PVC masterbatch and 95 kg of PVC slices were blended, and the antibacterial urinary catheter was produced through the catheter production process as usual.

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PUM

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Abstract

The invention relates to the technical field of medical apparatus and instruments, which discloses a sustained release type antibacterial medical catheter and a preparation method thereof. A silver inorganic antimicrobial is characterized by high content of silver, safety and the like, and the silver inorganic antimicrobial which adopts zirconium phosphate as a carrier is selected and mixed into catheter material to prepare the sustained release type antibacterial medical catheter that is most widely applied to clinic, such as an antibacterial catheter, an antibacterial central venous catheter, an antibacterial trachea cannula and the like. The catheter has high use safety, wide antibacterial spectrum, good antibacterial effects, antimicrobial constituent sustained release and long duration of antibacterial effects, and can reduce the frequency of replacing medical catheters so as to have safe and convenient clinical use, effectively reduce nosocomial infections related to catheters due to the use of the medical catheters, greatly reduce medical expenses related to anti-infection, and the like, and save medical resources.

Description

technical field [0001] The invention relates to the technical field of medical devices, and relates to a slow-release antibacterial medical catheter and a preparation method thereof. Background technique [0002] Medical catheters are widely used medical devices in clinical medical work. They are made of medical plastic catheter materials with or without plastic fillers. Medical catheters usually need to be implanted into the human body for invasive diagnosis and treatment, such as urinary catheters, central venous catheters, and endotracheal intubations. Medical catheters have become an important factor in concurrent catheter-related nosocomial infections, especially in patients with immunodeficiency or diabetes, infants, and the elderly, who are more prone to catheter-related infections. For example, urinary tract infection accounts for about 40% of nosocomial infections and is one of the most common nosocomial infections, among which about 50% are related to catheters. ...

Claims

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Application Information

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IPC IPC(8): A61L29/06A61L29/16
Inventor 瞿介明陶志清
Owner HUADONG HOSPITAL
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