Use of sulphonated calyx [5] arene in aspect of preparing medicament for treating toxicity of Paraguat
A technology of sulfonated cup and paraquat, which is applied in the field of biochemistry, can solve the problems of paraquat poisoning without specific antidote and effective treatment measures, and achieve good therapeutic effect, reduce toxicity and reduce the chance of exposure
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Embodiment 1
[0023] The first group of 10 18-20g healthy male Kunming mice were fed with 100 μL of normal saline as a control group, and observed continuously for 13 days. We found that the mice did not die (see figure 2 mouse survival curve). On the fourteenth day, the surviving mice were killed, weighed and dissected. The average body weight was 32.8 g (calculated from 4 randomly selected mice).
Embodiment 2
[0025] In the second group, 10 18-20g healthy male Kunming mice were fed with paraquat at a dose of 106.99 mg / kg, and observed continuously for 13 days. We found that the mortality rate of the mice was as high as 90%, and the deaths all occurred after the administration. the first three days (see image 3 mouse survival curve). On the fourteenth day, the only surviving mouse was killed, weighed and dissected. Its body weight was 14.0 g, the liver was dark red, the lungs were congested severely, and the lesions of the liver and lungs were obvious with the naked eye.
Embodiment 3
[0027] The third group of 10 18-20g healthy male Kunming mice were fed with sulfonated calix[5]arene at an equimolar dose to the second group, and observed continuously for 13 days. We found that the mice did not die (see Figure 4 mouse survival curve). On the fourteenth day, the surviving mice were killed, weighed and dissected. The average body weight was 33.4 g (calculated from 4 randomly selected mice). The liver and lungs were in good condition, and no lesions occurred in the naked eye. This indicates that the compound is non-toxic or of low toxicity.
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