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Process for preparing granisetron hydrochloride orally disintegrating tablets

A technology of granisetron hydrochloride and orally disintegrating tablets, which is applied in the fields of pill delivery, cardiovascular system diseases, and devices for making medicines into special physical or taking forms, etc. Poor stability, difficult to control and other problems, to achieve the effect of cool and delicate taste, small difference in tablet weight, and fast disintegration and dissolution

Active Publication Date: 2010-12-08
HONGYI SCI & TECH CO LTD NANCHANG
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0034] In China, the preparation technology of orally disintegrating tablets started relatively late. At present, most of the orally disintegrating tablets are prepared by direct compression method. The degree of crushing, disintegration, and dissolution are difficult to control, and the compressibility of the tablet is poor, so industrial production cannot be realized

Method used

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  • Process for preparing granisetron hydrochloride orally disintegrating tablets
  • Process for preparing granisetron hydrochloride orally disintegrating tablets
  • Process for preparing granisetron hydrochloride orally disintegrating tablets

Examples

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example 1

[0045]

[0046] Granisetron hydrochloride and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, cross-linked polyvinylpyrrolidone, aspartame, citrate, micronized silica gel, hard Magnesium fatty acid auxiliary materials were crushed separately, mixed and sieved according to the prescription weight ratio, and the final mixed fine powder was placed in a powder feeder for a new tablet press, and compressed to produce granisetron hydrochloride orally disintegrating tablets.

example 2

[0048]

[0049] Granisetron hydrochloride and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, cross-linked polyvinylpyrrolidone, aspartame, citrate, micronized silica gel, hard Magnesium fatty acid auxiliary materials were crushed separately, mixed and sieved according to the prescription weight ratio, and the final mixed fine powder was placed in a powder feeder for a new tablet press, and compressed to produce granisetron hydrochloride orally disintegrating tablets.

example 3

[0051]

[0052] Granisetron hydrochloride and mannitol, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, croscarmellose sodium, cross-linked polyvinylpyrrolidone, aspartame, citrate, micronized silica gel, hard Magnesium fatty acid auxiliary materials were crushed separately, mixed and sieved according to the prescription weight ratio, and the final mixed fine powder was placed in a powder feeder for a new tablet press, and compressed to produce granisetron hydrochloride orally disintegrating tablets.

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Abstract

The invention relates to a formula and a process of a granisetron hydrochloride orally disintegrating tablet with a direct powder tabletting method and a novel powder feed device for a tabletting machine. Compared with the conventional technology of direct powder tabletting, the granisetron hydrochloride orally disintegrating tablet manufactured with the invention has cool and fine mouth feel, small difference of tablet weight, favorable uniformity of content, fast disintegration and dissolution, high dissolution rate and dissolubility, strong rigidity and favorable compressibility.

Description

technical field [0001] The invention relates to a prescription and a process for producing granisetron hydrochloride orally disintegrating tablets by a direct powder compression method and a novel powder feeder for a tablet machine. Background technique [0002] Tumor has become the first enemy that threatens human life and health. According to a research report released by the International Cancer Research Center of the World Health Organization in May 2003, according to the current trend of cancer incidence, the incidence of cancer in the world in 2002 increased by 50% compared with the past, and the number of new cancer patients in the world will reach 1500 every year. million people. According to the research report of the center, the cancer with the highest incidence rate in the world is lung cancer, with 1.2 million new patients every year; breast cancer, with about 1 million new patients every year; followed by bowel cancer with 940,000 and 940,000 new patients. Sto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/439A61P9/10A61J3/10
Inventor 刘智钱进穆正义陶琳廖新华刘春阳熊水根陈晓华周治洋段建华颜锋刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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