Emulation device for coronary artery blood current changing with times

Abstract

The invention provides a stimulation device of time-phase characteristics of coronary artery blood flow, which relates to the technical field of in vitro stimulation experiments and aims at solving the technical problems that the existing hemodynamic parameters of clinical patients and experimental animals have randomness and the blood flow is difficult to be measured. The device comprises a fluid line system which consists of a cardiac pump, an accumulator, a fluid flow loop and a fluid storage tank which are sequentially and circularly connected, and a motor which drives the cardiac pump to move; and the device is characterized in that: the fluid flow loop comprises a two- position three-way valve, a diastolic branch and a systolic branch; one end of the diastolic branch and the systolic branch is respectively connected with two outlets of the two-position three-way valve, and the other end is connected with the fluid storage tank, a common inlet of the two-position three-way valve is connected with the accumulator, and the two-position three-way valve is driven by the motor to cause the common inlet to be communicated with the diastolic branch and the systolic branch along with the alternation of the diastole and the systole of the cardiac pump, and fluid resistance of the systolic branch is greater than that of the diastolic branch. By adopting the stimulation device of the invention, the time-phase characteristics of the coronary artery blood flow can be reproduced.

Description

technical field [0001] The invention relates to the technology of in vitro simulation experiment, in particular to the technology of a simulation device for the phase characteristic of coronary artery blood flow. Background technique [0002] The myocardial bundles covering the coronary arteries on the surface of the myocardium are called myocardial bridges. It is very important to understand the hemodynamic characteristics of the mural coronary arteries to objectively evaluate the clinical significance of myocardial bridges. [0003] The arteries that nourish the heart include the left and right coronary arteries, and the blood flow of the coronary arteries is affected not only by the contraction and relaxation of the coronary vessels themselves, but also by the rhythmic relaxation and contraction of the myocardium, especially the blood flow of the left coronary artery is more affected Significantly, when the left ventricle is isovolumic, due to the strong compression of th...

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Problems solved by technology

However, since the previous research objects were all clinical patients and experimental animals, there was a lack of a device that can simulate the coronary blood circulation system to reproduce the phasic characteristics of coronary blood flow, so there are the following limitations: 1) Lack of system, The randomness that affects hemodynamic parameters in clinical research subjects makes it difficult to conduct systematic and comprehensive clinical research; 2) the measurement of blood flow, coronary blood flow is the most important factor in determining the state of myocardial perfusion, but currently There is no clinically satisfactory method for measuring coronary blood flow, so there is insufficient understanding of the changes in mural coronary blood flow caused by myocardial bridging

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