External preparation for treating skin persistent ailment, e.g. tinea capitis, tinea corporis

A stubborn, skin technology, applied in the field of medical chemical manufacturing, can solve the problems of poor preparation permeability, poor effect durability, long medication time, etc., and achieve the effect of preventing skin dryness, less irritation, and good permeability

Inactive Publication Date: 2008-12-31
SHANGHAI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. Poor persistence of antibacterial and bactericidal effects
[0007] 2. Poor permeability of preparations, often only acting on the surface
[0008] 3. Drug resistance occurs after a long time of medication

Method used

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  • External preparation for treating skin persistent ailment, e.g. tinea capitis, tinea corporis
  • External preparation for treating skin persistent ailment, e.g. tinea capitis, tinea corporis
  • External preparation for treating skin persistent ailment, e.g. tinea capitis, tinea corporis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] see figure 1 , the present embodiment takes the preparation of 1000ml external water preparation as an example.

[0067] Preparation of water solution

[0068] 1. Take 200ml of acetic acid, add 100ml of deionized water, stir well and set aside.

[0069] 2. Add 200ml of glycerin, add 100ml of deionized water, stir well and set aside.

[0070] 3. Add 5ml of synthetic Chinese herbal medicine concentrate with a density of 1.04g / ml, add 95ml of deionized water, stir well and set aside.

[0071] Among them, the synthetic Chinese herbal medicine concentrates are the extracts of Saponaria thorn, Cnidium chinensis, Artemisia annua, Hemp willow leaves, Polygonum sp., Smilax cocos, Phyllostachys phylloxera, Artemisia argyi, white moss bark, Forsythia and Cypress leaves, which are synthesized and decolorized. And concentrated, concentrated to a density ≥ 1.04g / ml.

[0072] 4. Take 10ml of azone, add 10ml of ethanol, stir well and set aside.

[0073] Put the raw materials in 1-...

Embodiment 2

[0075] In this embodiment, the preparation of 1000 g of emulsion for external use is taken as an example.

[0076] 1. Take 70g of stearyl alcohol, 80g of monoglyceride, and 2g of ethylparaben, put them into the oil phase tank, heat to 90°C, and stir well

[0077] 2. Take 200g of glycerol, 6030g of Tween, and 393g of deionized water, put them into the water phase tank, heat to 90°C, and stir well

[0078] 3. Pump the material in the oil phase tank into the neutralization tank, start stirring, then pump the material in the water phase tank into the neutralization tank, continue stirring to make them fully contact and emulsify.

[0079] 4. When the temperature of the neutralization tank drops to 60°C, add 200 g of acetic acid and 5 g of synthetic Chinese herbal medicine concentrates with a density of 1.04 g / ml in sequence, wherein the synthetic Chinese herbal medicine concentrates are saponins, cnidium, artemisia annua, willow leaves, The extracts of Polygonum sativa, Smilax coc...

Embodiment 3

[0081] The present embodiment takes the preparation of 1000g cream for external use as an example.

[0082] 1. Take 10g sodium polyacrylate, add 250g deionized water, stir well and set aside.

[0083] 2. Take 200g of acetic acid, add 100g of deionized water, stir well and set aside.

[0084] 3. Take 200g of glycerol, add 100g of deionized water, stir well and set aside.

[0085] 4. Take 5g of synthetic Chinese herbal medicine concentrate with a density of 1.04g / ml, add 95g of deionized water,

[0086] 5. Take 10g of azone, add 10g of ethanol, stir well and set aside.

[0087] Add 2, 3, 4, and 5 to the mixing tank respectively, and slowly add the remaining amount of deionized water. After stirring evenly, add 1 and continue stirring. After it is fully dissolved, it can be filled.

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Abstract

The invention relates to an external application preparation for curing persistent ailment of ringworm of scalp and tinea corporis. The composing prescription contains industrial materials, such as glycerine, acetic acid , ethanol, deionized water, etc., wherein, composite Chinese herbal concentrated solution which is extracted from special medical materials, such as green fleabane, Chinese arborvitae leaf, blattbulume, Chinese honeylocust, argy wormwood leaf, common cnidium fruit, flaccid knotweed herb, cortex dictamni radicis, weeping forsythia capsule, glabrous greenbrier rhizome, Chinese wingnut leaf, and the like, is also added. The external application preparation of the invention has a preparation method that: the deionized water is added into acetic acid, then the composite Chinese herbal concentrated solution and the deionized water are added, in the acetic acid water solution, glycerine and the deionized water are added slowly, mixed and evenly stirred, then the azone ethanol mixing solution and the deionized water are added, mixed and evenly stirred, finally the external application preparation is obtained. The effective rate can reach up to 99 percent for curing the persistent ailment of ringworm of scalp and tinea corporis.

Description

technical field [0001] The invention relates to an external preparation for treating persistent skin diseases of tinea scalp and tinea corporis, belonging to the field of medical chemical manufacturing. Background technique [0002] Ringworm of the scalp is a scalp skin disease caused by Bacillus dander, often accompanied by itchy scalp symptoms. Almost everyone has dandruff bacteria on their scalp, and small amounts are not harmful. When the weather changes, or the human body causes hormonal changes due to stress, a large number of sebaceous glands gather on the epidermis of the head, providing a good growth environment for Bacillus dander. The massive growth of Bacillus dander accelerates the metabolism of scalp cells. Since ringworm is caused by Bacillus dander, the best way to treat it is to control the growth of the fungus. Pay attention to personal hygiene in daily life. [0003] Tinea corporis is ringworm that occurs on the face, neck, trunk and extremities. Anci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K47/22A61P17/00A61P31/10A61K31/19
Inventor 李静君张翊
Owner SHANGHAI UNIV
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