Nonoxynol nonylphenoxy-polyethoxyethanol suppositorium and preparation method thereof

Abstract

The invention discloses a novel nonoxynol-9 suppository and a preparation method thereof, and the nonoxynol-9 suppository is composed of the raw materials with the following weight portions of 1 portion of nonoxynol-9, 2 portions of polyethyleneglycol 1000 and 13 portions of mixed fatty glyceride. The nonoxynol-9 suppository of the invention optimally selects new stroma which replaces the traditional stroma adopted in the nonoxynol-9 suppository, solves the problems of the long response ( easy failure of contraception), easy oxidative rancidity, easy discoloration, difficult forming, great irration, and the like existing in the present nonoxynol-9 suppository, thereby having the advantages of short response, stable quality, difficult oxidative rancidity, avirulence, less irritation, no pollution to clothes in use, etc.

Description

Nonoxynol suppository and preparation method thereof technical field The invention relates to a suppository, in particular to a new nonoxynol suppository and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique Topical contraceptive spermicides have been developed on the basis of ancient folk traditional methods. Women have long known that putting some vinegar, soapy water or alum solution in the vagina can prevent pregnancy, and they also use highly toxic traditional Chinese medicine light powder. Later, people concluded that the acidic environment is not good for sperm, so they began to manufacture acidic external spermicide preparations, such as phenylmercuric acetate. However, mercury compounds are toxic to humans and have a killing effect on normal vaginal flora, which eventually leads to the growth of pathogenic bacteria and vaginitis. A new type of spermicide for external use is now used, that is, after the med...

AI Technical Summary

Problems solved by technology

The technical problem to be solved by the present invention is to overcome the defects such as slow onset of action, large irritation and poor stability of existing nonoxynol suppositories, and to provide a new nonoxynol suppository. It takes about 10 minutes to take effect after being placed on the site of action. In addition, the nonoxynol suppository also has the advantages of less irritation and good stability.

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