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Method for estimating major depression coming on susceptibility

A depression and susceptibility technology, applied in the field of judging the susceptibility of major depression, can solve the problem of not being able to accurately judge the susceptibility of major depression and the like

Inactive Publication Date: 2008-10-29
SHANXI MEDICAL UNIV
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Problems solved by technology

[0006] The present invention provides a method for judging the susceptibility of major depressive disorder in order to solve the problem in the prior art that the detection of NET gene or the evaluation of negative life events cannot accurately determine the susceptibility to the onset of major depressive disorder

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  • Method for estimating major depression coming on susceptibility
  • Method for estimating major depression coming on susceptibility

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Embodiment 1

[0029] 1.1 Research object

[0030] The subjects included patients with major depressive disorder (MD) in the outpatient department of the Mental Health Department of the First Hospital of Shanxi Medical University from May 2004 to March 2007, as well as healthy volunteers during the same period.

[0031] Case group: A total of 403 cases were enrolled, 10 cases without rs2242446 gene polymorphism molecular biology test results were excluded, 5 cases without rs5569 gene polymorphism test results were excluded, and finally 388 cases were included in the study. Among them, there were 185 males and 203 females, aged 16 to 63 years, with an average (32.26±12.20) years old, all of them were Han nationality. All patients were under the unified guidance, using the Diagnostic Investigation Genet Scale (DIGS) developed by Harvard University in the United States as a tool, and two psychiatrists who had undergone strict training and rich clinical experience uniformly followed the American...

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Abstract

The invention relates to the field of the association analysis between the gene-environmental interaction and the disease susceptibility, in particular to a method for judging the disease susceptibility of severe depression through detecting the associative action between a NET gene and negative life events. The method solves the problem that the disease susceptibility of the severe depression cannot be accurately judged yet in prior art through detecting the NET gene only or evaluating the negative life events only. First, the study object that is peripheral blood leukocyte DNA is extracted by a conventional phenol-chloroform method; the polymerase chain reaction and the direct sequencing DNA technique are adopted to detect the polymorphism of SNPs rs2242446 and rs5569 which are the NET gene; the genotype and the allele of examinees are determined; then the screening and the judgement of susceptible population are evaluated and performed through combining a life event scale so as to find that individuals are easier to be attacked by tristimania when suffering from the stimulus of certain life events, wherein, NET gene rs2242446 polymorphism basic groups of the individuals are C, and rs5569 polymorphism basic groups thereof are A.

Description

technical field [0001] The invention belongs to the field of correlation analysis between gene-environment interaction and disease susceptibility, and specifically relates to a method for judging the onset susceptibility of major depression by detecting the joint action of NET gene and negative life events. Background technique [0002] Major Depression (MD) is one of the most common mental disorders in humans, and its lifetime prevalence rate is 16.2% in the United States and 15% in China. It not only affects the individual's physical and mental health and social function, but also has a high risk of suicide. About 2 / 3 of depressed patients have suicidal ideation and behavior, and 10% to 15% of them commit suicide successfully. Not only that, but the recurrence rate of major depressive disorder is also very high, and it shows an upward trend with the increase of the number of illnesses. However, the clinical effective rate of existing antidepressants is only 60%-70%. Rece...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor 张克让孙宁徐勇杨红孙燕王彦芳段慧君彭菊意杜巧荣
Owner SHANXI MEDICAL UNIV
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