Process for extracting bacterial cell coenzyme Q10

Abstract

The invention relates to a technology for extracting coenzyme Q10 in bacterial cells, which pertains to the technical field of microbiology engineering. Thalli is automatically and quantitatively put into from the dog-house of a continuous countercurrent device under the control of a weigh-instrument, a solvent is injected from a solvent inlet under the control of a flowmeter and the leaching solution and the thalli form reverse continuous countercurrent leaching process under the push of a shovel-like thruster; the concentration gradient is large, relative movement exists between the solvent and the thalli and the thalli moves from the left end to the right end of an extraction container continuously under the function of the shovel-like thruster while the solvent moves from the right end to the left end of the container under the action of pressure; a diffusion boundary layer is thin and fast to be updated and the coenzyme Q10 is extracted after 2 to 10 hours of reaction of the thalli which enters from the left end of the device after the contact of the solvent and the thalli; the thalli enters a rake type dryer from the right end of an extraction device by press treatment and residual organic solvent in the thalli is treated with drying treatment in the rake type dryer; the yield of the coenzyme Q10 reaches more than 90 percent.

Description

technical field [0001] The invention belongs to the technical field of microbial engineering, in particular to a process for extracting coenzyme Q10 in bacterial cells. Background technique [0002] Coenzyme Q10 is a chemical component that widely exists in the cells of organisms and has no toxic side effects. It is the basis of energy production in human cells, and has a metabolic cardiotonic effect with definite effects. Coenzyme Q10 is mainly used in the treatment of acute and chronic viral hepatitis and acute hepatic necrosis. It has a very good curative effect on cardiovascular diseases and hypertension. It can also be used in the comprehensive treatment of cancer. etc. are uniquely effective. [0003] There are four main methods for producing coenzyme Q10 raw materials: biological extraction, solanesol semi-synthesis, chemical synthesis and microbial fermentation, among which microbial fermentation is recognized as the most advantageous and potential technology. The...

AI Technical Summary

Problems solved by technology

For large-scale extraction of active ingredients from bacteria, the traditional method has the following disadvantages: (1), when the bacteria and the extract reach a concentration balance, the mass transfer driving force will be lost, and the extract needs to be separated, and new solvents must be added for the second step. The second or third extraction takes a long time; (2), the later the batch extraction, the lower the concentration of the extract, resulting in the overall concentration of the extract mixture being much lower than the concentration of the first extract, increasing the The load of the concentration equipment; (3), the batch extraction must be filtered in batches and the solvent is reheated, so that the extraction tank is in an invalid operating state, and the extraction tank is wasted on many auxiliary operations, and the volumetric efficiency of the extraction tank is very low

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