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Applications of isobavachin for preparing antineoplastic, osteoporosis and senile dementia medicament

A tumor and pharmaceutical technology, applied in the field of medicine, can solve the problem of unclear role of non-classical estrogen membrane signaling pathway

Inactive Publication Date: 2008-08-27
BEIJING SHENOGEN BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of the non-canonical estrogen membrane signaling pathway is still unclear

Method used

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  • Applications of isobavachin for preparing antineoplastic, osteoporosis and senile dementia medicament
  • Applications of isobavachin for preparing antineoplastic, osteoporosis and senile dementia medicament
  • Applications of isobavachin for preparing antineoplastic, osteoporosis and senile dementia medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 In Vitro Biological Test of Formula (I) Compound

[0033] Test 1-1:

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Abstract

The invention relates to the use of bavachin in preparing drugs against tumors, osteoporosis and senile dementia, which belongs to the field of natural medicines. Bavachin has the structural formula shown as the figure (I). Experimental studies shows that the compound of formula (I), in low concentration, doesn't change the expressions of ERalpha66, ERalpha46 and ERalpha36, but in high concentration, inhibits the expressions thereof. Furthermore, the compound (I) can kill breast cancer cell line MCF7 that expresses ERalpha66, ERalpha46 and ERalpha36. The compound (I) can also be used as regulator of estrogen receptor ERalpha36 to treat diseases caused by abnormal expression of estrogen receptor ERalpha36, such as tumors, osteoporosis, asthma, heart diseases and senile dementia.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the application of natural compounds in the preparation of antitumor drugs, osteoporosis and senile dementia drugs. Background technique [0002] Estrogen is a steroid hormone produced by the endocrine system, which plays an important role in the reproductive system, bone tissue, cardiovascular system, immune system and central nervous system [J Cell Sci, 2003; 116(4): 585-586]. The estrogen signaling system plays an important role in the regulation of cell growth, differentiation and apoptosis. The occurrence and development of estrogen-dependent tumors, such as breast cancer, ovarian cancer and endometrial cancer, are closely related to estrogen [J SteroidBiochem.Mol.Biol., 2002, 81(1): 1-24, J Mammary Gland Biol. Neoplasia, 1998, 3(1): 49-61, Curr. Drug Targets Immune Endocr. Metabol. Disord; 2001, 1(1): 1-12, Cancer Res., 1998, 58(23) : 5367-5373, J Psychiatry Neurosci, 2002; 27 (1): ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P35/00
Inventor 李靖孟坤
Owner BEIJING SHENOGEN BIOMEDICAL
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