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Aminoglucose unsaturated fatty acid salt and application of the same in preparing medicament for curing nerve immunity incretion disease

An unsaturated fatty acid and glucosamine technology, which is applied in nervous system diseases, amino sugars, drug combinations, etc., can solve the problems of lack of biological signal guidance, gastrointestinal stimulation, and inconspicuous physiological effects, and achieves a simple and efficient process. Easy to implement, good clinical effect, low price effect

Inactive Publication Date: 2008-08-06
GUANGZHOU BAIEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucosamine hydrochloride and sulfate are drugs used in the treatment of human bone lesions. They are components of bone metabolism. The disadvantages are that their physiological effects are not obvious, they have no biological signal guiding effect, and they have a certain stimulating effect on the gastrointestinal tract.

Method used

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  • Aminoglucose unsaturated fatty acid salt and application of the same in preparing medicament for curing nerve immunity incretion disease
  • Aminoglucose unsaturated fatty acid salt and application of the same in preparing medicament for curing nerve immunity incretion disease
  • Aminoglucose unsaturated fatty acid salt and application of the same in preparing medicament for curing nerve immunity incretion disease

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0041] Accurately weigh 10 grams of glucosamine hydrochloride, add 5 grams of chemically pure oleic acid; grind for 20 minutes with a 500 rpm planetary grinder; add 35 ml of 95% ethanol and 15 ml of acetone, and let it settle for 30 minutes ; In the laboratory, filter with ordinary filter paper (Xinhua brand qualitative filter paper) in a simple device until the filtrate reaches a clear and transparent state; vacuum-dry for 30 minutes at a vacuum degree of -0.01 MPa and 60 ° C; grind it into a powder after drying , white or off-white glucosamine oleate, with sweet taste, soluble in water, hardly soluble in organic solvents, its molecular formula is C 24 h 47 NO 7 , molecular weight 461.64, molecular structure formula:

[0042]

[0043] The above medicines are made into tablets each containing 0.1 g of glucosamine oleate, and stored in a cool and dry place.

preparation Embodiment 2

[0045]Accurately weigh 11 grams of glucosamine hydrochloride, add 5 grams of chemically pure linoleic acid above; grind for 10 minutes with a 400 rpm planetary grinder; add 50 ml of ethanol with a concentration of 95% and let it stand for 45 minutes; Filter with ordinary filter paper (Xinhua brand qualitative filter paper) in a simple device until the filtrate reaches a clear and transparent state; vacuum-dry for 30 minutes at a vacuum degree of -0.01 MPa and 60°C; grind it into powder, white or White-like glucosamine linoleate, with sweet taste, soluble in water, hardly soluble in organic solvents, its molecular formula is C 24 h 45 NO 7 , molecular weight 459.64, molecular structure formula:

[0046]

[0047] The above-mentioned medicines are made into tablets each containing 0.1 g of glucosamine linoleate, and sealed and stored in a cool and dry place.

preparation Embodiment 3

[0049] Accurately weigh 9 grams of glucosamine hydrochloride, add 6 grams of chemically pure linolenic acid, and emulsify with a high-speed emulsifier at a rotation speed of 5,000 rpm for 15 minutes; add 45 ml of acetone, and let it settle for 30 minutes. Filter with ordinary filter paper (Xinhua brand qualitative filter paper) in the device until the filtrate reaches a clear and transparent state; vacuum-dry for 30 minutes at a vacuum degree of -0.02 MPa and 60°C; grind it into powdery white or off-white glucosamine Linolenate, with sweet taste, soluble in water, hardly soluble in organic solvents, its molecular formula is C 24 h 43 NO 7 , molecular weight 457.64, molecular structure formula:

[0050]

[0051] The above medicines are made into tablets each containing 0.1 g of glucosamine linolenate, and sealed and stored in a cool and dry place.

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Abstract

The invention relates to a chemical new drug of the medical technical field, in particular to a glucosamine unsaturated fatty salt and a relative application for preparing the drug of nerve immune endocrine disease. The preparation method comprises using glucosamine hydrochlorate as raw material, adding unsaturated fatty acid, emulsifying, depositing, filtering and drying to obtain glucosamine oleate, glucosamine linoleate and glucosamine linolenate to prepare the tablet with an effective component of 0.1g as the drug of nerve immune endocrine disease for I and II levels of Graves'disease exophthalmos patient with dropsy appearance and III and IV levels of Graves'disease exophthalmos patient and psychology physiologic sleep disorder patient, with the function of human internal biological signal molecule and high effect.

Description

technical field [0001] The invention relates to new chemical drugs in the field of medicine, in particular to unsaturated fatty acid salts of glucosamine and the application thereof in the preparation of drugs for treating neuroimmune endocrine diseases. Background technique [0002] Chinese patent ZL98113353.3 discloses a "application of chitin and its derivatives in pharmaceuticals", the basic substance of which is unsaturated fatty acid salt of chitin, which is used in the treatment of hyperthyroid exophthalmos (Graves' eye disease), psychophysiological sleep Good clinical results have been achieved in clinical trials of impairment of memory function and impairment of recent memory. [0003] Glucosamine unsaturated fatty acid salt is a monomer substance of chitin unsaturated fatty acid salt, which has a higher efficiency of absorption and transformation by passive objects and more significant clinical effect. However, as a drug, glucosamine hydrochloride is currently a r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/06A61K31/7008A61P25/20
Inventor 陈松伟
Owner GUANGZHOU BAIEN BIOTECH CO LTD
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