Aldol condensation catalyst and use thereof

A technology of aldol condensation and catalyst, which is applied in the field of aldol condensation catalyst and in the synthesis of 4-phenyl-3-buten-2-one, and can solve the problem of high price of phase transfer catalyst, troublesome post-processing, and difficult issues of industrial production

Inactive Publication Date: 2010-10-13
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the productive rate of phase-transfer catalysis is higher, phase-transfer catalyst is expensive, for example, triethylbenzyl ammonium chloride, crown ethers etc., and production cost is very high, is difficult for suitability for industrialized production; (2) supported solid base The catalyst preparation process is cumbersome, for example, the preparation of basic γ-alumina, etc., the post-treatment is troublesome, the yield is low, and it is not suitable for large-scale production

Method used

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  • Aldol condensation catalyst and use thereof
  • Aldol condensation catalyst and use thereof
  • Aldol condensation catalyst and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Select Al with a diameter of 0.6mm 2 o 3 Particles as carrier, with powdered 5% CaO, 4% MgO, 1% La 2 o 3 , 0.01% Pt, 0.02% Pd, the balance is Al 2 o 3 , after stirring evenly, add 5% sodium carboxymethylcellulose solution as a binder, stir to form uniform particles, dry, activate at 200°C for 2 hours, cool down to room temperature naturally, and put it in a desiccator for later use . The usual dosage is 0.5%. Abbreviation: ZD composite catalyst.

Embodiment 2

[0009] Select Al with a diameter of 0.8mm 2 o 3 Particles as carrier, with powdered 10% CaO, 3% MgO, 1.5% La 2 o 3 , 0.015% Pt, 0.01% Pd, the balance is Al 2 o 3 After stirring evenly, add an appropriate amount of sodium carboxymethylcellulose solution as a binder, stir to form uniform particles, dry, activate at 300°C for 1.5 hours, cool down to room temperature naturally, and put it in a desiccator for later use. The usual dosage is 0.5%. Abbreviation: ZD composite catalyst.

Embodiment 3

[0011] Choose Al with a diameter of 1mm 2 o 3 Particles as carrier, with powdered 15% CaO, 5% MgO, 2% La 2 o 3 , 0.02% Pt, 0.015% Pd, the balance is Al 2 o 3 After stirring evenly, add an appropriate amount of sodium carboxymethylcellulose solution as a binder, stir to form uniform particles, dry, activate at 200-300°C for 2 hours, cool down to room temperature naturally, and put it in a desiccator spare. The usual dosage is 0.5%. Abbreviation: ZD composite catalyst.

[0012] Utilize the catalyst of above-mentioned preparation to produce 4-phenyl-3-buten-2-one:

[0013] Add 100ml of benzaldehyde, 90ml of acetone and 1g of ZD composite catalyst in sequence in a 50ml round bottom flask equipped with a reflux tube, heat in a water bath at 80°C, stir for 6h with a magnetic force, and then filter to obtain a light yellow liquid, which is evaporated under reduced pressure for production.

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Abstract

The invention discloses an aldol condensation catalyst and application thereof in synthetization of 4-phenyl-3- butane-2-ketone. The invention is prepared by the weight percent of the following raw materials: 5-15: CaO percent, 3-5: MgO percent, 1-2: La2O3 percent, 0.01 to 0.02: Pt percent, 0.01 to 0.02: Pd percent, and the rest is Al2O3 percent. The aldol condensation catalyst has simple formula, is easy to be prepared and convenient in use, has good catalyst performance; in particular in aldol condensation preparation of the 4-phenyl-3- butane-2-ketone, the yield of the invention can reach above 95 percent, and the post-processing is simple; in addition, the invention has moderate response time, simple process, low production cost and is good for mass production.

Description

Technical field: [0001] The invention relates to a catalyst in the synthesis of an organic compound intermediate and its application, in particular to an aldol condensation catalyst and its application in the synthesis of 4-phenyl-3-butene-2-one. Background technique: [0002] Benzylidene acetone is an organic compound with a wide range of uses. It can be used as a raw material for the synthesis of perfumes, as a brightener in the electroplating industry, and as a stabilizer in pesticides; .Beijing: Chemical Industry Press, 1990, 181 and the document "Handbook of Synthetic Edible Flavors" compiled by Jinan Light Industry Research Institute. China Light Industry Press has discussed this. In addition, Cheng Jiahao in "Synthesis of Benzylidene Acetone by Phase Transfer Catalysis" [J]. Petroleum Technology and Application, 1992, (2): 89-92 also introduced that it has a strong sweet pea-type aroma, which is used for blending sweet pea series flavors and fruity food flavors, and i...

Claims

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Application Information

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IPC IPC(8): C07C45/72B01J23/63C07C49/217
Inventor 胡建立冉云根贾洪亮赵青松朱岭军
Owner ZHENGZHOU UNIV
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