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Preparation of medical bioavailability bracket material and uses thereof

A technology of biocompatibility and scaffold materials, applied in the field of preparation of medical biocompatible scaffold materials, can solve problems such as inability to maintain structure and mechanical strength, lack of porosity and uniform pores, limiting clinical application and curative effect

Active Publication Date: 2008-05-28
BEIJING BIOSIS HEALING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Studies have shown that although porcine small intestinal submucosa matrix has good histocompatibility, it can promote cell adhesion and reproduction in vitro, and maintain cell shape and phenotype, but it lacks good porosity and uniform pores, and in vivo Unable to maintain a certain structure and mechanical strength during the degradation process, which limits the clinical application and curative effect

Method used

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  • Preparation of medical bioavailability bracket material and uses thereof
  • Preparation of medical bioavailability bracket material and uses thereof
  • Preparation of medical bioavailability bracket material and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1: Preparation of Medical Biocompatible Scaffolding Materials Using Porcine Intestinal Tissue and Tendon Tissue or Dermal Tissue and Cartilage Tissue

[0066] Fresh small intestines were taken from pigs housed in closed housing, and the cleaning process was completed within 4 h. The mucosal, serosa, and muscular layers of the small intestine were removed by continuous rinsing with 40°C water during this process.

[0067] Soak the isolated porcine small intestine submucosa in a solution containing ethylenediaminetetraacetic acid (100mmol / L) and sodium hydroxide (10mmol / L) (pH value is 11-12) for 16h; then rinse with deionized water , soaked in a solution containing hydrochloric acid (1mmol / L) and sodium chloride (1mmol / L) (pH value is 0~1) for 6~8h; rinsed with deionized water, then soaked in sodium chloride (1mmol / L) Soak in phosphate buffered saline (PBS) for 16h; then rinse with deionized water and soak in PBS solution (pH 7-7.4) for 2h; rinse with deionized ...

Embodiment 2

[0072] Example 2: Preparation of Medical Biocompatible Scaffolding Materials Using Human Small Intestine Tissue and Tendon Tissue or Dermal Tissue and Cartilage Tissue

[0073] The raw materials used in this example are small intestine tissue and tendon tissue or dermal tissue and cartilage tissue of fresh human cadavers, and other preparation methods are the same as those in Example 1.

Embodiment 3

[0074] Example 3: Preparation of Medical Biocompatible Scaffolding Materials Using Bovine Intestinal Tissue and Tendon Tissue or Dermal Tissue and Cartilage Tissue

[0075] The raw materials used in this example are the small intestine tissue and tendon tissue or dermal tissue and cartilage tissue of cattle that were reared in closed enclosure, and other preparation methods were the same as those in Example 1.

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Abstract

The invention relates to a preparation and using method of medical biocompatible stent material. The medical biocompatible stent material is prepared by applying the small intestine submucosal and the tendon tissue of people or animals as the raw materials. The invention has good biocompatibility, appropriate porosity and mechanical strength and stable spatial structure, and the invention contains various growth factors to induce the tissue for regeneration and reconstruction, thereby improving the success rate of the repair of the various tissue defects and the reconstruction of tissue structures, therefore, the invention is an ideal tissue engineering material. The medical biocompatible stent material which is provided by the invention is applicable to the preparation of various tissue engineering equipments and the application in the repair of various tissue defects and injuries, including skin, blood vessels, nerves, tendons, bones, cartilages, abdominal walls, urinary tracts, oral mucosa and so on, and the invention can be used in the treatment of trauma, abdominal external hernia, anal fistula, rectovaginal fistula, rectum anterior protrusion, bone and cartilage defects, vascular injuries, nerve injuries, tendon injuries, oral mucosal injuries, relaxed pelvic floor, urinary tract injuries and other diseases.

Description

technical field [0001] The invention relates to a preparation of a medical biocompatible stent material and a method for using the same. The medical biocompatible scaffold material is prepared by using human or animal small intestinal submucosal tissue and tendon tissue as raw materials to prepare small intestinal submucosa matrix and collagen respectively, and then combine the acetic acid solution of the small intestinal submucosal matrix, the acetic acid solution of collagen and the sulfated cartilage prepared by mixing the solution. The material has good biocompatibility, more suitable porosity and mechanical strength, more stable spatial structure, and contains various growth factors, which can promote cell proliferation and adhesion, induce tissue regeneration and remodeling, and significantly improve the The success rate of repairing various tissue defects and remodeling tissue structure is a more ideal tissue engineering material. The medical biocompatible scaffold ma...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/54
Inventor 王振军赵博
Owner BEIJING BIOSIS HEALING BIOLOGICAL TECH
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