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Chemical medicine and natural medicine composition for treating diabetes chronic complication and preparation method thereof

A technology of natural medicines and compositions, applied in the field of medicine, can solve problems such as literature and patent reports on compound preparations that have not been seen

Inactive Publication Date: 2008-05-28
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Through the search, there are no relevant literature and patent reports on the compound preparations of the above-mentioned various drugs

Method used

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  • Chemical medicine and natural medicine composition for treating diabetes chronic complication and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 lipoic acid, ginkgo extract and methylcobalamin tablet

[0026] prescription:

[0027] components

Dosage

lipoic acid

Mecobalamin

Ginkgo Biloba Extract

microcrystalline cellulose

CMS-Na

Micropowder silica gel

Co-made

100g

0.5g

150g

90g

5g

4.5g

1000 pieces

[0028] Preparation:

[0029] Pass lipoic acid, ginkgo extract, and microcrystalline cellulose through an 80-mesh sieve, mix well, and set aside; take another appropriate amount of 50% ethanol solution, add methylcobalamin to dissolve, and use this solution as a binder to make a soft material. Granulate with a mesh sieve, dry at 50°C, granulate with a 20-mesh sieve, add micropowder silica gel and CMS-Na, mix well, and press a suitable die to form a tablet.

[0030] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteri...

Embodiment 2

[0032] Example 2 Prescription of methylcobalamin, lipoic acid, ginkgo biloba extract, astragalus polysaccharide, salvia miltiorrhiza, notoginseng, and crocodile granules:

[0033] components

Dosage

lipoic acid

Mecobalamin

Ginkgo Biloba Extract

Astragalus polysaccharide

Danshen

Notoginseng

Scrophulariaceae

Xylitol

stevioside

Micropowder silica gel

Co-made

100g

0.5g

150g

900g

9000g

1000g

9000g

90g

4.5g

4.5g

1000 bags

[0034] Preparation:

[0035] Pass lipoic acid, ginkgo extract, astragalus polysaccharide, Panax notoginseng, xylitol, and stevioside through 80-mesh sieves respectively, and set aside; take Salvia miltiorrhiza and Scrophulariae and extract twice with 50% ethanol under reflux, filter the extract, concentrate, and dry. Grind into fine powder; take an appropriate amount of 50% e...

Embodiment 3

[0037] Embodiment 3: Compound methylcobalamin, lipoic acid, calcium dobesilate, chondroitin sulfate, ginkgo extract capsules

[0038] prescription:

[0039] components

Dosage

lipoic acid

Mecobalamin

calcium dobesilate

Chondroitin Sulfate

Ginkgo Biloba Extract

starch

Magnesium stearate

Co-made

100g

0.5g

500g

150g

150g

10g

10g

2000 capsules

[0040] Preparation:

[0041] Pass lipoic acid, calcium dobesilate, chondroitin sulfate, and ginkgo extract through an 80-mesh sieve, mix them with starch evenly, and set aside; take another appropriate amount of 50% ethanol solution, add methylcobalamin to dissolve, and use this solution as Soft material made of binder, granulated with 24 mesh sieve, dried at 50°C, granulated with 20 mesh sieve, added with magnesium stearate, mixed evenly, and packaged separately to obtain the product.

[0042] ...

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Abstract

The invention relates to a series of combinations of chemical drug and natural drug used for treating diabetic chronic complications and the preparation method thereof, which are the combinations formed by one or a plurality of chemical drugs and one or a plurality of natural drugs, wherein, the chemical drug is any of mecobalamin, cobamamide, vitamin B12, epalrestat, lipoic acid and calcium dobesilate, and the natural drug is any of chondroitin sulfate, ginkgo biloba extract, astragalus polysaccharide, salvia miltiorrhiza, panax notoginseng and scrophularia. The preferred combination is: mecobalamin + lipoic acid + ginkgo biloba extract, mecobalamin + lipoic acid + ginkgo biloba extract + astragalus polysaccharide + salvia miltiorrhiza + panax notoginseng + scrophularia, mecobalamin + lipoic acid + calcium dobesilate + ginkgo biloba extract, mecobalamin + lipoic acid + chondroitin sulfate+ epalrestat + calcium dobesilate + ginkgo biloba extract, mecobalamin + lipoic acid + chondroitin sulfate + epalrestat + calcium dobesilate + ginkgo biloba extract + astragalus polysaccharide + salvia miltiorrhiza + panax notoginseng + scrophularia. The combinations are used for treating the microvessel and nerve lesions of diabetic chronic complications.

Description

technical field [0001] The invention relates to a series of chemical drugs and natural drug compositions for treating chronic complications of diabetes and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Diabetic peripheral neuropathy (DPN) is related to many factors, such as sugar alcohol metabolism disorder, Na+-K+-ATPase activity reduction, blood circulation disorder leading to blood hypercoagulability, abnormal blood cells, hardening of blood vessels, etc. The blood of DPN patients has thick, viscous, coagulation, aggregation and abnormal blood rheology and abnormal shape, vascular endothelial cells are damaged, blood vessels, especially microvascular walls are thickened, permeability is increased and microthrombosis is formed, resulting in nerve tissue ischemia and hypoxia. It causes enhanced oxidative stress and increased generation of free radicals, causing a series of oxidative reactions, leading to nerve dama...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K36/537A61K36/481A61K36/258A61K36/16A61K31/737A61P3/10A61P25/00A61K31/714A61K31/381A61K31/426A61K31/185
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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